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Polymers
Influence of talc and hydrogenated castor oil on the dissolution behavior of metformin-loaded…
Multi-unit pellet system (MUPS) is of great interest as it is amenable to customization. MUPS comprises multi-particulates, usually as pellets or spheroids, which can be coated with diffusion barrier coatings. One commonly used diffusion barrier coating is the methacrylic acid copolymer, which can…
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Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers
he development of polymer matrices as dental drug carriers takes into account the following technological aspects of the developed formulations: the composition and the technology used to manufacture them, which affect the properties of the carriers, as well as the testing methods for assessing…
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Cationic nanocapsule suspension as an alternative to the sublingual delivery of nifedipine
Nifedipine (NIFE) is a calcium channel blocker drug used to treat cardiovascular diseases, angina, and hypertension. However, NIFE is photolabile, has a short biological half-life, low aqueous solubility, and undergoes an intense first-pass effect, compromising its oral bioavailability. Thus, this…
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Nanostructured Lipid Carrier–Based Gel for Repurposing Simvastatin in Localized Treatment of Breast…
Simvastatin (SMV) is noticed as a repurposed candidate to be effective against breast cancer (BC). However, poor solubility, dose-limiting toxicities, and side effects are critical hurdles in its use against BC. The above drawbacks necessitate the site-specific (localized) delivery of SMV via …
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Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to…
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Taste Detection of Maltooligosaccharides with Varying Degrees of Polymerization
Previous studies have shown that humans can taste maltooligosaccharides but not maltopolysaccharides (MPS; DP of >20) and that their taste detection is independent of the canonical sweet taste receptor. The objectives of this study were to determine the DP ranges of target stimuli that are…
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Intranasal Insulin Delivery: Microparticle Formulations Consisting of Aloe vera Polysaccharides for…
Aloe vera gel and whole leaf materials, as well as polysaccharides, precipitated from the gel, have previously been shown to enhance macromolecular drug delivery across epithelial tissues. This study investigated the effectiveness of microparticle formulations prepared from A. vera polysaccharides…
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Development and Characterization of the Floating Beads Containing the BCS Class II Drug Lumafentrine…
Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Gastroretentive systems can remain in the gastric region for several hours and significantly prolong the gastric residence of the drugs. Prolonged gastric retention improves bioavailability,…
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Viscoelastic Behavior of Supercooled and Glassy ASDs at Humid Conditions Can Be Predicted
Amorphous solid dispersions (ASDs) are commonly used to increase the dissolution rate of poorly soluble active pharmaceutical ingredients (APIs). Unfortunately, most ASDs are thermodynamically unstable and, even though kinetically stabilized, will thus eventually crystallize. The crystallization…
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Synergistic Encapsulation of Paclitaxel and Sorafenib by Methoxy Poly(Ethylene…
Ovarian cancer has a high mortality rate due to difficult detection at an early stage. It is necessary to develop a novel anticancer treatment that demonstrates improved efficacy while reducing toxicity. Here, using the freeze-drying method, micelles encapsulating paclitaxel (PTX) and sorafenib…
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