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Polymers
Unlock the Potential of Poorly Soluble Drugs with Apisolex™ Technology
Don’t let poor solubility affect your innovative drug projects
Approximately 60% of potential active pharmaceutical ingredients (APIs) under development, and more than 40% of those in reformulation, are poorly water soluble1. Solubility challenges present a substantial hurdle to the development…
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Mucoadhesion matters – by Lubrizol
And so does your choice of mucoadhesive polymer.
Choose Carbopol® polymers and Noveon® polycarbophil.
Mucoadhesion is a type of bioadhesion in which two materials, at least one of which is mucosal, are held together for extended periods by interfacial forces.
To successfully achieve…
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Compaction Behavior of Co-Amorphous Systems
Co-amorphous systems have been shown to be a promising strategy to address the poor water solubility of many drug candidates. However, little is known about the effect of downstream processing-induced stress on these systems. The aim of this study is to investigate the compaction properties of…
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Enteric coating of drug loaded aerogel particles in a wurster fluidized bed and its effect on…
Ibuprofen loaded and unloaded alginate aerogel particles were successfully coated with methacrylic acid-ethyl acrylate copolymer in a Wurster fluidized bed. Pores of both aerogels were well-preserved during the coating process. Effects of drug loading, polymer rheology, and atomizing pressure on…
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Electrospun nanofibres in drug delivery: advances in controlled release strategies
Emerging drug-delivery systems demand a controlled or programmable or sustained release of drug molecules to improve therapeutic efficacy and patient compliance. Such systems have been heavily investigated as they offer safe, accurate, and quality treatment for numerous diseases. Amongst newly…
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Recent Progress of Lipid Nanoparticles-Based Lipophilic Drug Delivery: Focus on Surface…
Numerous drugs have emerged to treat various diseases, such as COVID-19, cancer, and protect human health. Approximately 40% of them are lipophilic and are used for treating diseases through various delivery routes, including skin absorption, oral administration, and injection. However, as…
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Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions—The Effect of Different Types of…
Four model polymers, representing (i) amorphous homopolymers (Kollidon K30, K30), (ii) amorphous heteropolymers (Kollidon VA64, KVA), (iii) semi-crystalline homopolymers (Parteck MXP, PXP), and (iv) semi-crystalline heteropolymers (Kollicoat IR, KIR), were examined for their effectiveness in…
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Overcoming Challenges in Ophthalmic Formulations through Polymer Selection
Ophthalmic drugs are delivered to the eye to treat chronic diseases such as dry eye and acute conditions such as inflammation and infections.
The market for drugs administered to the eye is growing, in large part, due to our aging population and the increased prevalence of eye-related conditions…
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Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for…
Hydroxypropyl methylcellulose (HPMC) is an important polymeric excipient. Its versatility in terms of molecular weights and viscosity grades is the basis for its wide and successful application in the pharmaceutical industry. Low viscosity grades of HPMC (like E3 and E5) have been used as physical…
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Vitamin E TPGS-Based Nanomedicine, Nanotheranostics, and Targeted Drug Delivery: Past, Present, and…
It has been seventy years since a water-soluble version of vitamin E called tocophersolan (also known as TPGS) was produced; it was approved by USFDA in 1998 as an inactive ingredient. Drug formulation developers were initially intrigued by its surfactant qualities, and gradually it made its way…
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