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Polymers
Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a…
The study aims to investigate the ability of lyophilized nasal inserts of nanosized atomoxetine HCl solid lipid nanoparticles (ATM-SLNs) to transport atomoxetine (ATM) directly to the brain and overcome the first-pass metabolism. In this case, 16 formulae of (ATM-SLNs) were prepared using hot melt…
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Implementation of Quality by Design (QbD) for Development of Bilayer Tablets
Bilayer tablets offer various drug release profiles for individual drugs incorporated in each layer of a bilayer tablet, which is rarely achievable by conventional tablets. These tablets also help avoid physicochemical incompatibilities between drugs and excipients. Successful manufacturing of such…
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Evaluating Spray Drying and Co-precipitation as Manufacturing Processes for Amorphous Solid…
Amorphous solid dispersions feature prominently in the approach to mitigate low bioavailability of poorly water-soluble small molecules, particularly in the early development space focusing on toxicity evaluations and clinical studies in normal healthy volunteers, where high exposures are needed to…
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Amorphous Solid Dispersions Layered onto Pellets – An Alternative to Spray Drying?
Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting fine powders usually require further downstream processing when intended for solid oral dosage forms. In this study, we compare properties and…
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Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement.…
Abstract
Introduction
Mucoadhesive drug delivery systems (MDDS) are specifically designed to interact and bind to the mucosal layer of the epithelium for localized, prolonged, and/or targeted drug delivery. Over the past 4 decades, several dosage forms have been developed for localized as…
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Design and Evaluation of Sustained Release Bilayer Tablets of Oxcarbazepine
Objective
The aim of the present study is to modify the release profile of oxcarbazepine by formulating it as a bilayer tablet using direct compression method with dual compression.
Methods
In the bilayer system, the immediate release layer was formulated using four types of disintegrants, sodium…
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Controlled delivery via hot-melt extrusion: A focus on non-biodegradable carriers for non-oral…
Hot-melt extrusion (HME) has an esteemed place in the pharmaceutical industry with significant applications and advancements spreading over 30 years of development. Currently, the choice of matrix excipients is vast, expanding from all different kinds of synthetic polymers to natural carriers.…
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Hydroquinone cream-based polymer microneedle roller for the combined treatment of large-area…
Melasma is a common hyperpigmented skin condition that occurs on the face and other areas prone to light exposure, seriously affecting people's quality of life. Microneedle, a new type of transdermal drug delivery device, can significantly improve skin permeability. In this study, we designed and…
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Micro-Scale Vacuum Compression Molding as a Predictive Screening Tool of Protein Integrity for…
Hot-melt extrusion (HME) is used for the production of solid protein formulations mainly for two reasons: increased protein stability in solid state and/or long-term release systems (e.g., protein-loaded implants). However, HME requires considerable amounts of material even at small-scale (>2 g…
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Enhancement of itraconazole solubility and release by hot-melt extrusion with Soluplus®
Formulation of poorly water-soluble drugs is a significant challenge in the development of oral solid dosage forms. The objective was to investigate the effect of hot-melt extrusion process and formulation variables on the solid state, solubility and release of an ionizable poorly soluble drug,…
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