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Polymers
Use of polyvinyl alcohol (PVA) to overcome challenges in ophthalmic formulations
Successful ophthalmic drug formulations rely on the selection of the correct polymer to ensure the desired characteristics such as retention in the eye cavity and solubility. One example of such an excipient is polyvinyl alcohol (PVA) which offers many advantages for ophthalmic drug formulations…
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The applications of machine learning to predict the forming of chemically stable amorphous solid…
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various benefits, including a solvent-free process, continuous…
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Effects of polyvinylpyrrolidone and poly (ethylene glycol) on preparation of ibuprofen…
In this study, we investigated the effects of polymers on the pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as the active pharmaceutical ingredient (API), nicotinamide (NIC) and saccharin (SAC) as the cocrystal coformer (CCF), ethanol/water as the solvent,…
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who advances drug delivery? we do. – pharmaceutical product and solution guide by Ashland
advancing drug delivery
Ashland’s pharmaceutical team prides itself on advancing drug delivery with sophisticated science-based solutions. Our global centers of excellence contain the latest equipment and our research scientists and formulators are ready to work with you from concept to…
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Enhancing Intradermal Delivery of Lidocaine by Dissolving Microneedles: Comparison between…
Lidocaine hydrochloride (LiH), an amide-type local anesthetic agent, is commonly used in dermatological procedures. LiH is categorized as a BCS (biopharmaceutics classification system) class III group, which has high solubility and poor permeability. It should be noted that, in this context, LiH is…
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Tackling the Trends – How Excipient Technologies Enable Oral Solid Innovation
Did you know that between 2015 and 2019, 70% to 80% of new molecular entities (NMEs) approved by the FDA were small molecules, and, in 2019, 68% of small molecules approved were oral dosage delivery?
Although drug delivery innovations in other areas may receive more excitement and coverage, for…
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The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly…
Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioavailability. This work provides a comprehensive investigation…
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Machine learning models to accelerate the design of polymeric long-acting injectables
Long-acting injectables are considered one of the most promising therapeutic strategies for the treatment of chronic diseases as they can afford improved therapeutic efficacy, safety, and patient compliance. The use of polymer materials in such a drug formulation strategy can offer unparalleled…
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Transform Your Brick-Dust API into an Effective oral Drug Candidate with Apinovex Polymers
Lubrizol Apinovex™ polymers can be easily incorporated into your drug project via spray drying or other solvent-based processes. This novel excipient has a broad API and solvent compatibility to produce Amorphous Solid Dispersions (ASD) of your brick-dust API.
1. Unlock the Potential Of…
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Extrusion for pharma applications: An update
This paper aims to give an overview of our current research and development on hot-melt extrusion (HME) for pharmaceutical formulation and drug delivery. Unfortunately, a large percentage of marketed drugs (40%) and those in the development pipeline (90%) are poorly water soluble.
We use a few…
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