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Polymers
A New Method to Determine Drug-Polymer Solubility Through Enthalpy of Melting and Mixing
In this study, a new method to determine the solubility of crystalline drugs in (amorphous) polymers is proposed. The method utilizes annealing of supersaturated amorphous solid dispersions to achieve equilibrium between dissolved and recrystallized drug. By measuring the enthalpy of melting and…
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Impact of Aluminum Oxide Nanocoating on Drug Release from Amorphous Solid Dispersion Particles
Atomic layer coating (ALC) is emerging as a particle engineering strategy to inhibit surface crystallization of amorphous solid dispersions (ASDs). In this study, we turn our attention to evaluating drug release behavior from ALC-coated ASDs, and begin to develop a mechanistic framework.…
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Electrospinning as a method for preparation of redispersible dry product with high content of…
One of the key technological challenges in the development of iron-oxide-based magnetic nanoparticles (MNPs) is their long-term physical stability in colloidal dispersions. This can be improved by their transformation into a dry form. Here, we introduce electrospinning as a drying method for…
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Development and characterization of amphotericin B nanoemulsion-loaded mucoadhesive gel for…
Despite being recognized as the “gold standard” for treating azole-resistant vulvovaginal candidiasis, amphotericin B (AmB), an amphoteric molecule, has not been widely used due to serious issues with solubility and permeability. In light of the aforementioned, the objective of the present study was…
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Selecting the most appropriate formulation excipient for manufacture of amorphous solid dispersions:…
This work demonstrated the importance of pre-formulation studies and proposed a generalised scheme for excipient screening in the early stage of amorphous solid dispersion (ASD) system development by profiling the excipients’ capability to solubilise, amorphisise, and stabilise the chosen active…
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Redox responsive poly(allylamine)/eudragit S-100 nanoparticles for dual drug delivery in colorectal…
Herein, we report redox responsive, colon cancer targeting poly(allylamine) (PA)/eudragit S-100 (EU) nanoparticles (PAEU NPs) (≈59 nm). These disulfide crosslinked PAEU NPs are developed via air oxidation of thiolated PA and thiolated EU, eliminating the need of any external crosslinking agent for…
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Sustained and targeted delivery of hydrophilic drug compounds: A review of existing and novel…
The sustained and/or targeted delivery of hydrophilic drugs is an important field within drug delivery, presenting unique challenges when compared to that of hydrophobic drugs. Yet relatively few comprehensive reviews specific to hydrophilic drug delivery have been published recently. In this…
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Days or Centuries? – Predicting the Shelf-Life of ASDS
PURPOSE
Amorphous solid dispersions (ASDs) are a state-of-the-art enabling formulation technique for poorly water-soluble drugs. Drug recrystallization in the polymer matrix highly unwanted: marks end of shelf life of such a formulation.
Overcoming the poorly understood drug recrystallization…
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Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, Egels are attracting a great deal of interest in the biomedical space.…
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How to Improve Solubility and Dissolution of Irbesartan by Fabricating Ternary Solid Dispersions:…
The purpose of this study is to improve the solubility and dissolution of a poorly soluble drug, Irbesartan, using solid dispersion techniques. For that purpose, different polymers such as Soluplus®, Kollidon®VA 64, Kolliphor®P 407, and Polyinylpyrrolidone (PVP-K30) were used as carriers at…
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