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Polymers
Existing and emerging mitigation strategies for the prevention of accidental overdose from oral…
Misadventure with pharmaceutical oral medication has been on the rise, with the opioid crisis playing a major part. Drug overdose related to opioids has become such an issue, that it has been labelled a worldwide crisis. This review explores the mitigation strategies currently in place to prevent…
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Design and Development of Dual Functional Colon Targeted Eudragit/Chitosan Nanoparticles: A QbD…
Aim: The goal of this study was to develop colon-targeted nanoparticulate systems of the anti-inflammatory agent Quercetin (QU) and evaluate the formulation for various parameters that would allow the active ingredient to be released at a predetermined time and location with better pharmaceutical…
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When coating runs smoothly – Parteck® COAT: Reduce your process time with an optimized polymer…
Our broad range of formulation products covers excipients for solid, semi-solid and liquid dosage forms for small and large molecules. Additionally, we offer a portfolio of drug delivery compounds (DDCs), as well as solutions for solubility enhancement and controlled release. Benefit from our…
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Role of 3D Printing in the Development of Biodegradable Implants for Central Nervous System Drug…
Increased life expectancy has led to a rise in age-related disorders including neurological diseases such as Alzheimer’s disease and Parkinson’s disease. Limited progress has been made in the development of clinically translatable therapies for these central nervous system (CNS) diseases. Challenges…
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Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine
Infected chronic skin wounds and other skin infections are increasingly putting pressure on the health care providers and patients. The pressure is especially concerning due to the rise of antimicrobial resistance and biofilm-producing bacteria that further impair treatment success. Therefore,…
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Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through…
The objective of this work was to optimize a thermosensitive in situ gelling formulation to improve intranasal and nose-to-brain delivery of the antiepileptic drug carbamazepine (CBZ). A preliminary procedure of vehicles obtained just mixing different fractions of poloxamer 407 (P407) and poloxamer…
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Encapsulation of polyphenols in pH-responsive micelles self-assembled from octenyl-succinylated…
An amphiphilic polymer based on octenyl succinic anhydride-modified curdlan oligosaccharide (MCOS) was synthesized. The critical micelle concentration of MCOS was 3.91 μg·mL−1. MCOS could self-assemble into spherical micelles with a particle size of 230.1 nm and a zeta potential of − 37.9 mV. When…
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Performance comparison of PLA- and PLGA-coated porous bioceramic scaffolds: Mechanical,…
Bioceramics, particularly calcium phosphates, bioactive glasses, and crystalline silicates, are a principal group of biomaterials employed for the regeneration of damaged tissues and therapeutic delivery. The development of ceramic tissue engineering scaffolds with an appropriate combination of…
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Recent advancements in polymeric nanofibers for ophthalmic drug delivery and ophthalmic tissue…
Nanofibers due to their unique properties such as high surface-to-volume ratio, porous structure, mechanical strength, flexibility and their resemblance to the extracellular matrix, have been researched extensively in the field of ocular drug delivery and tissue engineering. Further, different…
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Metronidazole nanosuspension loaded dissolving microarray patches: An engineered composite…
Bacteroides fragilis is one of the most common causative group of microorganisms that is associated with skin and soft tissue infections (SSTI). Metronidazole (MTZ) is the drug of choice used in the treatment of SSTI caused by the bacterium. However, owing to its physiochemical properties, MTZ have…
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