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Polymers
Preparation of Eudragit S100-pullulan/hydroxypropyl-β-cyclodextrin complex-Eudragit S100 multilayer…
Cyclodextrin-based electrospun nanofibers are promising for encapsulating and preserving unstable compounds, but quick dissolution of certain nanofibers hinders their delivery application. In this study, hydroxypropyl-β-cyclodextrin (HPβCD) was used as an effective carrier of resveratrol (RSV) to…
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Acrylic co-polymer and organic acid-based press coated pulsatile tablet of nifedipine using 32…
Many diseases exhibit circadian fluctuation, including diabetes, asthma, rheumatoid arthritis, and hypertension. These disorders cannot be effectively treated with conventional dosage forms and instead require time-scheduled drug release for pharmacological effectiveness.
The objective of this…
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Shifting from sustained to delayed drug delivery systems: Encapsulated mesoporous silica-chitosan…
The current study demonstrates a desired drug delivery-controlled system with a wide range of release parameters. It illustrates the feasibility of carriers in the systems for extended and short drug release. Herein, mesoporous silica nanoparticles (MSNs) coated with chitosan (Cs) grafted polylactic…
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Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic…
Abstract
Liraglutide (LIRA) is a glucagon-like peptide-1 (GLP-1) receptor agonist renowned for its efficacy in treating type 2 diabetes mellitus (T2DM) and is typically administered via subcutaneous injections. Oral delivery, although more desirable for being painless and potentially enhancing…
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Nanocarriers for Controlled Release and Target Delivery of Bioactive Compounds
See the new book, edited by Shaba Noore , Shivani Pathania , Pablo Fuciños , Colm P. O'Donnell , Brijesh K. Tiwari.
Description: This brief provides a comprehensive overview of nanocarriers used for nanoencapsulation of bioactive compounds. It includes the basis of encapsulation mechanism,…
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Opportunities and Challenges: Process Raman for the Real-Time Release Testing (RTRT) of…
Abstract
The use of a process analytical technology has been demonstrated using near-infrared spectroscopy for continuous manufacturing of pharmaceutical formulations and is within the scope of the U.S. Food and Drug Administration's real-time release testing initiative. While effective for simple…
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Nano-encapsulation of probiotics: Need and critical considerations to design new non-dairy probiotic…
People worldwide need to improve their health or intention to control diseases more naturally through ingredients incorporated into foods and beverages, called functional foods. Functional foods include probiotic organisms and bioactive compounds incorporated into dairy and fermentable foods, whose…
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In Situ Gelling Nasal Drug Delivery System
Abstract
In the nasal cavity, nasal mucosa had a high blood perfusion rate, due to this the absorption of the drug is high as compared to other routes, as well as has increased good bioavailability of drugs at the systemic circulation. To improve the nasal retention time of in-situ gel with nasal…
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Enhancing breast cancer treatment: Comprehensive study of gefitinib-loaded poloxamer 407/TPGS mixed…
Abstract
Breast cancer continues to pose a substantial global health challenge, emphasizing the critical need for the advancement of novel therapeutic approaches. Key players in the regulation of apoptosis, a fundamental process in cell death, are the B-cell lymphoma 2 (Bcl-2) family proteins,…
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Spray drying Eudragit® E-PO with acetaminophen using 2- and 3-fluid nozzles for taste masking
Conventional spray drying using a 2-fluid nozzle forms matrix microparticles, where drug is distributed throughout the particle and may not effectively mask taste. In contrast, spray drying using a 3-fluid nozzle has been reported to encapsulate material. The objective of this study was to spray dry…
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