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Polymers
Application of electrostatic dry powder coating technology on capsules to achieve sustained release
This study introduces an electrostatic dry powder coating process to coat hard gelatin capsules and hydroxypropyl methylcellulose capsules directly in a coating pan to achieve sustained release. The process overcomes many difficulties in the capsule liquid coating process, such as stickiness and…
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Biodegradable polymers for parenteral drug delivery
Functional lactide/glycolide polymers play a key role in complex parenteral drug delivery products. They are often referred to as ‘smart’ materials, as their tunability drives the performance of parenteral dosage forms. Using these polymers, formulators can deliberately change drug impact by…
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Formulation and optimization of Paliperidone palmitate biodegradable injectable microspheres using…
The objective of study was to formulate and optimize poly lactic-co-glycolic acid based long-acting injectable microspheres of Paliperidone palmitate (PP) using Box- Behnken design for treatment of schizophrenia. The oral bioavailability of PP is 28%, it necessitates the formulation of PP in…
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The Use of Sodium Alginate in Extended Release Tablet Formulations
Extended release tablets are commonly based on partially synthetic cellulose ethers, such as hypromellose (HPMC), hydroxyethyl cellulose (HEC), or hydroxypropyl cellulose (HPC). Alginates offer an interesting, all-natural alternative to these polymers. The aim of the present study was to…
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Formulation of sustain release matrix tablet of anti-anginal drug based on Eudragit L 100-55:…
This study aims to design and evaluate oral sustained release matrix tablets of BCS class 2 anti-anginal drug using Eudragit L 100-55 as the retardant polymer and mannitol as a channeling agent for the delivery of anti-anginal drug as twice-daily dose. The tablets were made using the traditional wet…
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Carbopol® Polymers: The Key to Unlocking Patient-Centric OTC Innovation
Did you know that as many as 40% of children have difficulty swallowing a normal-sized pill?
Formulate with patient needs in mind with Lubrizol Life Science Health’s comprehensive excipient range, including Carbopol® polymers, enabling patient-centric formulations with properties such as:…
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Production, physicochemical investigations, antioxidant effect, and cellular uptake in Caco-2 cells…
The purpose of this study was to develop astaxanthin (AST)-loaded self-microemulsifying drug delivery system (SMEDDS) tablets and evaluate their physicochemical and biological properties. The optimized liquid (L)-AST SMEDDS formulation was composed of rice bran oil (33.67%), Kolliphor® RH 40…
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In vivo and in vitro per se effect evaluation of Polycaprolactone and Eudragit® RS100-based…
Biodegradable polymeric nanocapsules (NC) present incredible characteristics as drug nanocarriers that optimize drug targeting. However, However, a more detailed isolated effect of polymer-based nanoparticles as drug carriers is required. This work aimed to evaluate the per se effect of blank-NC…
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Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric…
The goal of this study was to use polymeric konjac glucomannan (KGM), Kollidon VA 64 (KVA64), and glutaraldehyde to ameliorate stomach specific floating microspheres (SSFM) using domperidone (DoN) to increase in vivo bioavailability and emerging health pathologies. The SSFM were made using the…
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Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers
In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on…
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