Browsing Category
Polymers
Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers
In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on…
Read More...
Read More...
Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded…
Lornoxicam (LRX) is a potent nonsteroidal anti-inflammatory drug (NSAID) used extensively to manage pain and inflammatory conditions. However, the drug possesses poor aqueous solubility (i.e., BCS class II) and a short half-life (3–4 h). Mucoadhesive buccal tablets containing LRX -loaded solid lipid…
Read More...
Read More...
An Insight into Preparatory Methods and Characterization of Orodispersible Film—A Review
Over the past few decades, researchers and companies have been trying to develop novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are expensive, complex, and time-consuming processes, but trends are moving toward…
Read More...
Read More...
The Use of Polymer Blends in the Treatment of Ocular Diseases
The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug…
Read More...
Read More...
Non-invasive drug delivery systems mediated by nanocarriers and molecular dynamics simulation for…
Local deliver medication in a non-invasive pattern and attaining a long-term sustained release at ocular regions to minimize side effects is fascinating for treatment and precision medicine, but its rational design remains a challenge. The aim of this study was to analyze the effect of different…
Read More...
Read More...
Pharmacokinetic control on the release of antimicrobial drugs from pH-responsive electrospun wound…
The acidic pH of healthy skin changes during wound healing due to the exposure of the inner dermal and subcutaneous tissue and due to the potential colonization of pathogenic bacteria. In chronic non-healing wounds, the pH values vary in a wide pH range but the appearance of an alkaline shift is…
Read More...
Read More...
Kollidon® VA 64 and Soluplus® as modern polymeric carriers for amorphous solid dispersions
As the number of new drug candidates that are poorly soluble in water grows, new technologies that enable the enhancement of their solubility are needed. This is the case with amorphous solid dispersions (ASDs) that, nowadays, not only ensure the solubility, but can also be used to control the …
Read More...
Read More...
Downstream Processing of Itraconazole:HPMCAS Amorphous Solid Dispersion: From Hot-Melt Extrudate to…
The downstream processing of hot-melt extruded amorphous solid dispersions (ASDs) into tablets is challenging due to the low tabletability of milled ASDs. Typically, the extrudate strand is sized before milling, as the strand cannot be fed directly into the milling system. At the lab scale, the…
Read More...
Read More...
Research progress of poly(methyl methacrylate) microspheres: Preparation, functionalization and…
Poly(methyl methacrylate) (PMMA) microsphere is a kind of spherical polymer particles, which is polymerized from methyl methacrylate (MMA) monomer by initiator. Monodisperse diameter, excellent biocompatibility, superior transparency and diverse chemical group evolved from ester group empower it…
Read More...
Read More...
Manufacture of Tablets with Structurally-Controlled Drug Release using Rapid Tooling Injection…
With advancements in the pharmaceutical industry pushing more towards tailored medicines, novel approaches to tablet manufacture are in high demand. One of the main drivers towards micro-scale batch production is the ability to fine-tune drug release. This study demonstrates the use of rapid tooling…
Read More...
Read More...