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Polymers
A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions:…
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in recent years, with the potential to improve the apparent solubility and, hence, the oral bioavailability of poorly soluble drugs. The process of formulating ASDs is commonly faced with challenges owing to the…
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Optimization and evaluation of resveratrol amorphous solid dispersions with a novel polymeric system
The preparation of amorphous solid dispersions using polymers is a commonly used formulation strategy for enhancing the solubility of poorly water-soluble drugs. However, a single polymer often does not bring significantly enhance the solubility or amorphous stability of a poorly water-soluble drug.…
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Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion
A series of thermoresponsive diblock copolymer worm gels is prepared via reversible addition–fragmentation chain transfer (RAFT) aqueous dispersion polymerization of 2-hydroxypropyl methacrylate using a water-soluble methacrylic precursor bearing pendent cis-diol groups. Selective oxidation using an…
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In vitro-in vivo correlation of PLGA microspheres: Effect of polymer source variation and…
Development of Level A in vitro-in vivo correlations (IVIVCs) remains challenging for complex long-acting parenterals, such as poly(lactic-co-glycolic acid) PLGA microspheres. The nature of the PLGA polymer excipient has a dominant influence on the performance of PLGA microspheres. These microsphere…
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Polymer selection to increase in vitro supersaturation generated by lamotrigine nicotinamide…
Cocrystals can improve drug dissolution by generating supersaturated drug delivery systems. However, supersaturation is a high-energetic state with a tendency to precipitate. Polymers are used as precipitation inhibitors to inhibit nucleation or crystal growth. Our aim was to evaluate the influence…
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Thermal Analysis Tools for Physico-Chemical Characterization and Optimization of Perfluorocarbon…
Self-emulsifying microbubbles, especially designed to increase the contrast of ultrasound images by the inclusion of perfluorocarbon molecules, have been studied by thermal analysis techniques. The microbubbles were made of a blend of gas (20%), surfactants (50%) and water (30%). The surfactants…
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Poloxamer 188 as Surfactant in Biological Formulations – An Alternative for Polysorbate 20/80?
Surfactants are used to stabilize biologics. Especially, polysorbates (Tween® 20 and Tween® 80) dominate the group of surfactants in protein and especially antibody drug products. Since decades drug developers rely on the ethoxylated sorbitan fatty acid ester mixtures to stabilize sensitive…
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Pharmaceutical, Biomedical and Ophthalmic Applications of Biodegradable Polymers (BDPs): Literature…
In the last few decades, the interest in biodegradable materials for biomedical applications has increased significantly. Both natural and synthetic biodegradable polymers (BDPs) have been broadly explored for various biomedical applications. These include sutures and wound dressings, screws for…
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Polyurethane foams from vegetable oil-based polyols: a review
Polyurethane is a versatile material that can be converted into various forms according to applications. PU foams or PUFs are the most commonly used polyurethanes. These are materials of low density and low thermal conductivity that make them highly suitable for thermal insulating applications. Most…
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Nanocarriers for promoting skin delivery of therapeutic agents
Compared to oral and injectable administration, a dermal and transdermal drug delivery system that can deliver therapeutic molecules to desired target sites with noninvasive, low toxicity, and convenient self-application is a unique method with high potential and excellent prospects. However, the…
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