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Polymers
Design and optimization of pH-sensitive Eudragit nanoparticles for improved oral delivery of…
Design of Experiments (DoE) techniques were used to identify and optimize the parameters involved in the formulation of triclabendazole pH-sensitive Eudragit® nanoparticles (NPs). Using a Placket Burmann design, Eudragit® E, Eudragit® RS, and two stabilizers (PVP and PVA) were evaluated for NPs…
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Resveratrol-Loaded Vesicular Elastic Nanocarriers Gel in Imiquimod-Induced Psoriasis Treatment: In…
This work aimed to develop a new efficient approach for safe treatment of psoriasis. To achieve that, resveratrol-loaded spanlastics (F1-F12) were prepared and evaluated by complete in vitro characterization. The two optimal formulations (F10 and F11) had their particle size in the nano range with…
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Lyophilized tablets of felodipine-loaded polymeric nanocapsules to enhance aqueous solubility:…
The aim of this study was to enhance the physicochemical properties of felodipine through the formulation of lyophilized polymeric nanocapsule tablets. Felodipine was loaded into polymeric nanocapsules composed of Labrafac™ PG (an oil solubilizer) and Eudragit® EPO (cationic coating polymer) using…
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Formulation and characterization of curcumin nanoparticles for skin cancer treatment
Curcumin possesses remarkable chemotherapeutic activity owing to its anti-inflammatory and anti-oxidant properties. Purpose of the research work was to prepare curcumin-loaded nanoparticles of Eudragit E 100 for topical skin applications through a simple, cost-effective method of nanoprecipitation.…
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Eudragit® L100/chitosan composite thin bilayer films for intravaginal pH-responsive release of…
The high rate of HIV new infections and AIDS-related deaths each year make prevention tools still necessary today. Different dosage forms – including films – for vaginal administration of antiretroviral drugs have been developed for this purpose. Six batches of Tenofovir-loaded films were formulated…
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3D printing of pharmaceutical oral solid dosage forms by fused deposition: the enhancement of…
3D printing (3DP) by fused deposition modelling (FDM) is one of the most extensively developed methods in additive manufacturing. Optimizing printability by improving feedability, nozzle extrusion, and layer deposition is crucial for manufacturing solid oral dosage forms with desirable properties.…
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Dose-independent Drug Release from 3D Printed Oral Medicines for Patient-specific Dosing to Improve…
Fused deposition modelling (FDM) 3D printing provides the ability to address individual patients’ therapeutic needs without having to change the formulation every time. This is particularly interesting for dosing and release modelling. In this study, a geometry model was developed that can represent…
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Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior…
A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which a 2:1 stoichiometric ratio was found by powder and single-crystal X-ray diffraction analysis. Cocrystal CTD-CAF showed a supramolecular organization in which CAF…
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Revealing the roles of polymers in supersaturation stabilization from the perspective of…
Formulating drugs into amorphous solid dispersions (ASDs) represents an attractive means to enhance the aqueous solubility of drugs. Furthermore, water-soluble polymers have proven highly advantageous for stabilizing supersaturated solutions of ASDs. However, the performance and mechanism of various…
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Moisture sorption by polymeric excipients commonly used in amorphous solid dispersion and its effect…
Moisture plays a critical role in the stability of amorphous solid dispersions (ASD) as it can lower the glass transition temperature (Tg) and thereby increase molecular mobility resulting in drug crystallization. A systematic study on moisture sorption by four polyvinylpyrrolidone (PVP) having…
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