Browsing Category
Polymers
Moisture sorption by polymeric excipients commonly used in amorphous solid dispersion and its effect…
Moisture plays a critical role in the stability of amorphous solid dispersions (ASD) as it can lower the glass transition temperature (Tg) and thereby increase molecular mobility resulting in drug crystallization. A systematic study on moisture sorption by four polyvinylpyrrolidone (PVP) having…
Read More...
Read More...
FDM 3D-Printed Sustained-Release Gastric-Floating Verapamil Hydrochloride Formulations with…
The aim of this work was to design and fabricate fused deposition modeling (FDM) 3D-printed sustained-release gastric-floating formulations with different shapes (cylinder, capsule and hemisphere) and infill percentages (0% and 15%), and to investigate the influence of shape and infill percentage on…
Read More...
Read More...
Eudragit coated microemulsion for enhanced efficacy of spiramycin against toxoplasmic encephalitis
The study investigated Eudragit coated microemulsion (ME) for oral delivery of spiramycin in treatment of toxoplasmic encephalitis. The goal was to augment the efficacy of ME by protection from gastrointestinal conditions and/or providing bioadhesion. Uncoated and coated MEs comprise labrafil as…
Read More...
Read More...
PCL-PEG copolymer based injectable thermosensitive hydrogels
A number of stimuli-responsive-based hydrogels has been widely explored in biomedical applications in the last few decades because of their excellent biodegradability and biocompatibility. The development of synthetic chemistry and materials science leads to the emergence of in situ …
Read More...
Read More...
Factors Influencing the Crystallization-Onset Time of Metastable ASDs
In formulation development, amorphous solid dispersions (ASD) are considered to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). However, the crystallization of APIs often limits long-term stability and thus the shelf life of ASDs. It has already been…
Read More...
Read More...
Concept of Orodispersible or Mucoadhesive “Tandem Films” and Their Pharmaceutical Realization
Orodispersible or mucoadhesive films as a patient-oriented dosage form for low-dosed drugs are usually produced using solvent casting. This paper presents a modification of the solvent casting technique that aimed to divide oral films into two or more compartments.
The proposed objectives and…
Read More...
Read More...
The Effect of Polymers on Drug Release Kinetics in Nanoemulsion In Situ Gel Formulation
Glaucoma is an ocular condition characterized by elevated intraocular pressure (IOP). Conventional treatments of glaucoma face poor corneal permeability and bioavailability. To address these issues, a nanoemulsion in situ gel of Timolol maleate was developed in this study by adding the polymer…
Read More...
Read More...
Tablet Disintegration and Dispersion under In Vivo-like Hydrodynamic Conditions
Disintegration and dispersion are functional properties of tablets relevant for the desired API release. The standard disintegration test (SDT) described in different pharmacopoeias provides only limited information on these complex processes. It is considered not to be comparable to the biorelevant…
Read More...
Read More...
Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions:…
Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are desirable for improving oral absorption of amorphous solid dispersions. The present study investigates the impact of binary and ternary amorphous solid dispersions on the supersaturation kinetics of nifedipine…
Read More...
Read More...
ExciPerience – Early Bird sale ends on January 31st
ExciPerience is the virtual event around every aspect of pharmaceutical excipients. ExciPerience covers all areas from basic or advanced research and formulation to manufacturing and regulatory. There will be more and new possibilities for personal interaction and different presentation formats than…
Read More...
Read More...