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Polymers
Development and evaluation of nano-formulations for immediate release oral dosage forms of poorly…
Inaugural-Dissertation to obtain the academic degree Doctor rerum naturalium (Dr. rer. nat.) submitted to the Department of Biology, Chemistry, Pharmacy of Freie Universität Berlin by Zun Huang
Solubility and dissolution rate are essential for the oral absorption and thus bioavailability of…
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Apinovex™ Polymers – the Key to Addressing Solubility Challenges in Oral Formulations
Between 40-70% of marketed drugs and up to 90% of all new chemical entities (NCEs) suffer from poor water solubility, meaning they don’t readily dissolve in an aqueous solution. This has significant negative consequences for the bioavailability of the active pharmaceutical ingredient (API), with an…
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Electrospun poly(ω-pentadecalactone-co-ε-caprolactone)/gelatin/chitosan ternary nanofibers with…
In recent years, there is an increasing attention on biocompatible electrospun nanofibers for drug delivery applications since they provide high surface area, controlled and sustained drug release, and they mimic the extracellular matrix. In the present study, tetracycline hydrochloride (TCH)…
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Eudragit S100 prepared pH-responsive liposomes-loaded betulinic acid against colorectal cancer in…
This study aimed to develop polymer Eudragit S100 for preparing pH-responsive liposomes-loaded betulinic acid (pH-BA-LP) to improve the therapeutic index of chemotherapy for colorectal cancer. BA-loaded liposomes were coated with Eudragit S100 by a thin film dispersion and easily scalable pH-driven…
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Design and physico-mechanical evaluation of fast-dissolving valsartan polymeric drug delivery system…
Objective(s): Chronic hypertension is a pervasive morbidity and the leading risk factor for cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and bioavailability. The application of orodispersible films of valsartan is suggested to improve its bioavailability. With…
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Microfluidic-Generated Immunomodulatory Nanoparticles and Formulation-Dependent Effects on…
Nanoparticles (NPs) have emerged as a highly useful and clinically translatable drug delivery platform for vast therapeutic payloads. Through the precise tuning of their physicochemical properties, NPs can be engineered to exhibit controlled drug release properties, enhanced circulation times,…
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Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres
The purpose of this research is to investigate the suitability of acquiring improved dissolution profile and sustained release of Fluvastatin sodium to reduce dosage frequency via a novel combination of freeze dried microspheres and Eudragit polymers-based matrix tablet technologies. Fluvastatin…
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DoE approach for development of localized controlled release microspheres of Vancomycin for…
Background
Septic arthritis is a worse condition of RA that is associated with significant morbidity and mortality. Septic arthritis develops due to direct introduction or invasion of pathogens. The objective of the present study was to formulate Vancomycin hydrochloride-loaded microspheres (VMS)…
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PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application
Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of…
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The Expanded Role of Chitosan in Localized Antimicrobial Therapy
Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the…
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