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Polymers
The Expanded Role of Chitosan in Localized Antimicrobial Therapy
Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the…
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Solving Compactability Issues for the Preparation of ODTs
Introduction
Formulators often face compactability issues for the preparation of orally disintegrating tablets (ODTs) where active pharmaceutical ingredients (APIs) are poorly compressible or formed in a coated pellet. HiSORAD™, one of the best-in-class co-processed excipient for ODT, may work as…
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Influence of Print Settings on the Critical Quality Attributes of Extrusion-Based 3D-Printed…
Extrusion-based 3D-printing is an easy-to-use, cheap manufacturing technique that could be used to produce tailored precision medicines. The technique has an almost unlimited versatility since a multitude of print parameters can easily be adapted. Unfortunately, little is known of the effect of…
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Phase behaviour and characterization of micelles of graft copolymer Soluplus® and non-ionic…
The present study deals with the self-assembly of a pure graft copolymer: Soluplus® and a non-ionic surfactant: Solutol® HS15 and focuses on their clouding behaviour in the presence of different additives viz. inorganic salts (NaF, NaCl, NaBr, NaI, NaNO3, KCl, KBr, KI), bile salts (sodium…
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Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge…
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Effects of crosslinking on the physical solid-state and dissolution properties of 3D-printed…
Crosslinking is an established treatment to alter the physicochemical and functional properties of polymers through the creation of bonds between the polymer chains. Polymers can be crosslinked via radiation in the presence of photo-initiator. The aim of the present study was to formulate 3D-printed…
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Towards a Better Understanding of Verapamil Release from Kollicoat SR:IR Coated Pellets Using…
The aim of this study was to gain deeper insight into the mass transport mechanisms controlling drug release from polymer-coated pellets using non-invasive analytical tools. Pellet starter cores loaded with verapamil HCl (10% loading, 45% lactose, 45% microcrystalline cellulose) were prepared by…
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Oral insulin delivery by epithelium microenvironment-adaptive nanoparticles
Oral protein drug delivery using nano-based systems remains challenging, as contradictory surface properties are required for efficient navigation through the intestinal mucus and epithelium barriers. Therefore, new nanoplatforms with tunable surface properties in vivo are urgently needed. Inspired…
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Optimized Rivastigmine Nanoparticles Coated with Eudragit for Intranasal Application to Brain…
Rivastigmine, a reversible cholinesterase inhibitor, is frequently indicated in the management of demented conditions associated with Alzheimer disease. The major hurdle of delivering this drug through the oral route is its poor bioavailability, which prompted the development of novel delivery…
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Quantification and characterization of water within drug-eluting beads
This work describes the analysis and characterisation of polyvinylalcohol (PVA)-based hydrogel polymer beads, specifically focussing on the quantitative and qualitative aspects of water within such beads in the absence and presence of three drugs; doxorubicin and irinotecan (already utilised as…
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