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Polymers
Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral…
There have been many efforts to improve oral drug bioavailability and therapeutic efficacy and patient compliance. A variety of controlled-release oral delivery systems have been developed to meet these needs. Gastroretentive drug delivery technologies have the potential to achieve retention of the…
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The interactions in ternary system made of xanthan gum, Carbopol 940 and anionic/nonionic surfactant
The development and optimization of systems consist of polymers and surfactants are strongly related to the presence of interactions between them. Therefore, the interpolymer complexes between biopolymer xanthan gum and synthetic polymer Carbopol 940 were investigated before and after the addition…
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Novel graphene oxide loaded sodium alginate hydrogels cross-linked with tetraethyl orthosilicate for…
In this work, novel graphene oxide (GO) loaded (0–40 mg), sodium alginate (Na-Alg) hydrogels were prepared using tetraethyl orthosilicate (TEOS) as a silane cross-linker and then characterized by FTIR and XRD analysis, TGA and SEM analysis, as well as swelling test in water, ionic and buffer…
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Big family of nano- and microscale drug delivery systems ranging from inorganic materials to…
Traditional drug administration routs suffer from low selective distribution, poor solubility, fast elimination and damaging adjacent healthy tissues (especially in cancer therapy). Thus, drug delivery systems (DDSs) which could deliver drug to target site have broadly been investigated to upsurge…
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Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based…
Betulinic acid (3β-Hydroxy-20(29)-lupaene-28-oic acid, BA) has excellent anti-cancer activity but poor solubility and low bioavailability. To improve the antitumor activity of BA, a polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol (PVCL–PVA–PEG) graft copolymer (Soluplus) encapsulated BA…
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INSTACOAT 4G: Innovative tablet coating formulation
INSTACOATTM 4G is a ready-mixed powder that can be rapidly reconstituted in water, for the film coating of solid oral dosage forms. It contains polymer, plasticizer, pigments, etc. in optimal ratios to achieve significant benefits in terms of processability and product quality.
It is available in…
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Effects of Surface Pretreatment of Titanium Substrates on Properties of Electrophoretically…
The preparation of the metal surface before coating application is fundamental in determining the properties of the coatings, particularly the roughness, adhesion, and corrosion resistance. In this work, chitosan/Eudragit E 100 (chit/EE100) were fabricated by electrophoretic deposition (EPD) and…
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Development of Glimepiride Loaded Sustained Release Microparticles Using Tubular Microreactor
Background: Glimepiride is a third-generation, oral anti-diabetic sulfonylurea drug, generally recommended for the treatment of type–II diabetes. A biocompatible polymer, Eudragit RS 100 is widely used for the preparation of targeted and time-controlled release of drugs. Glimepiride is encapsulated…
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Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in…
Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and…
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Formulation development and in-vitro evaluation of dexlansoprazole loaded double walled microspheres
In the present work, double walled microspheres of Dexlansoprazole using Sodium alginate, HPMC E15, Xanthan gum, Ethyl cellulose as copolymers and along with Carbopol were formulated to deliver Dexlansoprazole through oral route. Details regarding the preparation and evaluation of the formulations…
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