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Polymers
Dapsone-Loaded Microsponge Gel for Acne Management: Preparation, Characterization and Anti-Microbial…
Background: Acne vulgaris is a chronic inflammatory disorder involving Propionibacterium acnes and activation of lymphocytes and neutrophils. Dapsone (sulfone drug) possesses potent anti-microbial activities and hence, it is used to cure multiple inflamed acne lesions. Howbeit, its therapeutic…
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Vinyl Polymer-based technologies towards the efficient delivery of chemotherapeutic drugs
The application of synthetic polymers as delivery systems of chemotherapy drugs has opened a very prospective field for research in cancer therapy. Due to their unique and attractive properties - biocompatibility, non-carcinogenicity, non-immunogenicity, non-toxicity, ease of functionalization, and…
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Nanostructured Fluids For Polymeric Coatings Removal: Surfactants Affect the Polymer Glass…
Hypothesis: Nanostructured fluids (NSFs) based on water, organic solvents and surfactants are a valid alternative to the use of neat unconfined organic solvents for polymer coatings removal in art conservation. The physico-chemical processes underpinning their cleaning effectiveness in terms of…
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Preclinical study of methotrexate-based hydrogels versus surfactant based liquid crystal systems on…
Psoriasis is an autoimmune, inflammatory and chronic skin disease in which cell growth and proliferation are increased, causing erythema, lesions and skin's peeling. Oral methotrexate (MTX) is the first-choice drug when phototherapy or retinoid treatment are not effective. Topical administration can…
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Biomedical Applications of Biodegradable Polymers in Wound Care
According to the World Health Organization, it is estimated that 180,000 deaths occur annually due to burns. In the United States, it is expected that chronic wounds (e.g., diabetic and pressure ulcers) affect 6.5 million people. Thus, skin lesions are a public health problem that imposes the…
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Microneedle array with a pH-responsive polymer coating and its application in smart drug delivery…
For successful wound treatment, therapeutics must be delivered directly to the wound. Various issues restrict the delivery of antibiotics to wounds, including the barrier mannered by necrotic tissue and biofilms, which create an extracellular polymeric layer that impedes the efficient…
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Hierarchical Bayesian approach applied to the formulation of sustained-release suppositories and…
The hierarchical Bayesian modeling approach was used to select the appropriate empirical kinetics model of sustained release and to optimize the in vitro dissolution rate of the sustained-release suppository by controlling the composition of Eudragit L-100 and Eudragit S-100 in the experimental…
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Impact of Matrix Surface Area on Griseofulvin Release from Extrudates Prepared via Nanoextrusion
We aimed to examine the impact of milling of extrudates prepared via nanoextrusion and the resulting matrix surface area of the particles on griseofulvin (GF, a model poorly soluble drug) release during in vitro dissolution. Wet-milled GF nanosuspensions containing a polymer (Sol: Soluplus®, Kol:…
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Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed…
Although hot melt extrusion (HME) has been used in combination with fused deposition modelling (FDM) three-dimensional printing (3DP), suitable feedstock materials such as polymeric filaments with optimum properties are still limited. In this study, various release modifying excipients, namely,…
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Polymer nanoparticles-preparations, applications and future insights: a concise review
Nanosized particles have appealing attributes, which have gotten impressive consideration in the last few decades. Polymeric nanoparticles (PNP)s are particles or particulate materials with size at least in the range of 10–100 nm in one dimension. Due to the extremely small size, high volume-surface…
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