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Polymers
Preparation and characterization of Eudragit L 100-55/chitosan enteric nanoparticles containing…
Background and purpose: Omeprazole (OMP) is broadly used for the treatment of gastroesophageal reflux and other acid-related diseases. The current study aimed to prepare enteric-coated nanoparticles containing OMP to achieve a stable powder formulation easily prescribed in children.
Experimental…
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A Trusted Solutions Provider To Adress Poor Drug Solubility
THE DRUG SOLUBILITY SPECIALIST FOR SOLID DISPERSIONS, PARTICLE ENGINEERING AND SILICA TECHNOLOGIES
Almost half of currently marketed drug products, and around 90 % of those in clinical development are associated with poor drug solubility or permeability. A multitude of factors can affect drug…
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Tetrahydrocurcumin encapsulation in cyclodextrins for water solubility improvement: synthesis,…
The solubility of the scarcely water-soluble molecule tetrahydrocurcumin (THC), a promising curcumin derivative to be used as biopesticide, was enhanced through the formation of inclusion complexes with different cyclodextrins (CDs). Randomly methylated β-cyclodextrin (MeβCD) gave the best results…
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The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using…
In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated. The drug–polymer combinations were studied with regard to the influence of (i) the physicochemical properties of the…
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Segmented intravaginal ring for the combination delivery of hydroxychloroquine and anti-CCR5 siRNA…
Vaginal drug delivery has been shown to be a promising strategy for the prevention of sexually transmitted infections. Therapy delivered at the site of infection has many advantages including improved therapeutic efficacy, reduction in systemic toxicity, and reduced potential for development of drug…
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Pectin based multi-particulate carriers for colon-specific delivery of therapeutic agents
In case of colon-specific delivery of therapeutic agents through oral route, microbial/enzyme-triggered release approach has several advantages over other approaches due to unique microbial ecosystem in the colon. Multiple-unit carriers have an edge over single-unit carriers for this purpose. Among…
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The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of…
The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting…
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The Effect of Process Variables and Binder Concentration on Tabletability of Metformin Hydrochloride…
In twin screw melt granulation, granules are produced by passing mixtures of drug substances and polymeric binders through twin screw extruder such that temperatures are maintained below melting point of drugs but above glass transition of polymers used, whereby the polymers coat surfaces of drug…
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Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution…
Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as…
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Tablet Excipients – Virtual Video Lessons in Hindi & English by Dr. Tarun Virmani
We provide this virtual lessons by Dr. Tarun Virmani, Associate Professor, MVN University, especially for our Indian Audience.
Drug products usually contain inactive, non-medicinal substances other than the therapeutic agent(s). These substances are called excipients, and they are…
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