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Polymers
Fused deposition modeling of API-loaded mesoporous magnesium carbonate
In this thesis, the incorporation of drug loaded mesoporous magnesium carbonate as an excipient for the additive manufacturing of oral tablets by fused deposition modeling was investigated. Cinnarizine, a BCS class II drug, was loaded into the pores of the mesoporous material via a soaking method,…
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Polymeric Materials to Improve the Stability and Delivery of Insulin and Glucagon
Proteins and peptides have become an important class of therapeutics due to their high specificity and general biocompatibility. However, using proteins and peptides as drugs has several intrinsic challenges. These macromolecules are generally cleared rapidly due to renal filtration and enzymatic…
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The Stabilizing Excipients in Dry State Therapeutic Phage Formulation
Phage therapy has gained prominence due to the increasing pathogenicity of “super bugs” and the rise of their multidrug resistance to conventional antibiotics. Dry state formulation of therapeutic phage is attractive to improve their “druggability” by increasing their shelf life, improving their…
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Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for…
The purpose of this study was to develop Pickering water-in-oil nano-emulsions only stabilized by Eudragit RL100 nanoparticles (NPs), in order to increase the nano-emulsion stability and create a barrier to improve the drug encapsulation and better control the drug release. The first part of this…
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Polyvinyl Alcohol (PVA) for Tablet Coating Applications: Enhancing Formulation Flexibility
Purpose: Polyvinyl alcohol (PVA) is a well-established polymer for film coating. PVA is a synthetic, bio-compatible and toxicologically well characterized polymer. It is frequently used in pre-mixed coating formulations. Fixed combinations with additional ingredients are well established. By…
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Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules. However, the information of ATBC on its pharmacokinetics is…
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Soluplus solutions as thermothickening materials for topical drug delivery.
Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This material could have application topical drug delivery to sites including the…
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3D printed devices in the gastrointestinal tract of rodents – imaging by PET/CT
04. December 2017
Abstract
Fused deposition modelling (FDM) 3D printing (3DP) is a revolutionary technology with the potential to transform drug product design in both the pre-clinical and clinical arena. The objective of this pilot study was to explore the intestinal behaviour…
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Diblock Terpolymers Are Tunable and pH Responsive Vehicles To Increase Hydrophobic Drug Solubility…
28. September 2017
Synthetic polymers offer tunable platforms to create new oral drug delivery vehicles (excipients) to increase solubility, supersaturation maintenance, and bioavailability of poorly aqueous soluble pharmaceutical candidates. Five well-defined diblock terpolymers…
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Hot melt extrudates formulated using design space: improved palatability and dissolution
31. August 2017
This work aimed to obtain an optimized itraconazole (ITZ) solid oral formulation in terms of palatability and dissolution rate by combining different polymers using hot melt extrusion (HME), according toa simplex centroid mixture design. For this, the polymers…
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