Browsing Category
Polymers
A novel release retarding polymer for direct compression
17. August 2017
For the development of this excipient for direct compression no chemical modification was applied. The enhanced functionality enabling a nearly zero order release was achieved by techniques such as physical mixing, high shear mixer granulation and spray drying.…
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The wettability and swelling of selected mucoadhesive polymers in simulated saliva and vaginal…
22. May 2017
Abstract
The surface properties play a particularly important role in the mucoadhesive drug delivery systems. In these formulations, the adsorption of polymer matrix to mucous membrane is limited by the wetting and swelling process of the polymer structure. Hence,…
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Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into…
19. April 2017
Abstract
We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid…
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The functionality and stability of HPMCAS when used in hot-melt extrusion
31. March 2017
The majority of today’s new chemical entities are poorly water-soluble. One widely used means of overcoming that problem is to develop solid dispersions by mixing at the molecular level the drug candidate into a polymer matrix . Spray drying and hot-melt extrusion…
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Formulation and evaluation of nasal in situ gel of phenylephrine hydrochloride
24. March 2017
Abstract
In situ gel drug delivery systems are in solution form before administration but once administered, undergo gelation in situ, to form a gel. In the present study nasal in situ gel of Phenylephrine hydrochloride was prepared for the treatment of nasal…
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Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion…
Abstract
In the present study, we aimed to prepare a gastroretentive drug delivery system that would be both highly resistant to gastric emptying via multiple mechanisms and would also potentially induce in situ supersaturation. The bioadhesive floating pellets, loaded with an amorphous…
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Natural Polymers for Drug Delivery – Book
20. January 2017
Main Description
Natural polymers have been utilized extensively in food, pharmaceuticals, cosmetics, textiles, oil drilling and paint industries. Their non-toxic and inexpensive attributes readily enhance their commercial acceptability and make them potent agents in…
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Engineering hot-melt extruded solid dispersion for controlled release of hydrophilic drugs
Abstract
It is often challenging to precisely manipulate the release behavior of hydrophilic drugs that is believed to be crucial for a satisfactory therapeutic outcome. The aim of this work was to regulate the dissolution of hydrophilic drug from hot-melt extruded solid dispersion via…
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Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug…
10. January 2017
Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS) was developed, which consisted of chitosan (CTN) based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The…
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Efavirenz dissolution enhancement III: Colloid milling, pharmacokinetics and electronic tongue…
03. January 2017
Abstract
Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), is part of first-line therapy for the treatment of human immunodeficiency virus type 1 infection (HIV-1/AIDS). This drug shows relatively low oral absorption and bioavailability, as…
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