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Polymers
Thermal Processing of PVP- and HPMC-Based Amorphous Solid Dispersions
Abstract
Thermal processing technologies continue to gain interest in pharmaceutical manufacturing. However, the types and grades of polymers that can be utilized in common thermal processing technologies, such as hot-melt extrusion (HME), are often limited by thermal or rheological…
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Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol…
27. December 2016
Abstract
Purpose: To design controlled release ketorolac tromethamol (KT) matrix tablets for increased drug bioavailability.
Methods: Waxes (Compritol® ATO 888, Precirol® ATO 5 and stearic acid - SA) and polymers (hydroxypropyl methylcellulose - HPMC and xanthan gum…
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Complication with Order: Understanding the Structure-Property Relationship of Polymers for their…
09. November 2016
Complication with Order: Understanding the Structure-Property Relationship of Polymers for their Application in Drug Delivery
In modern pharmaceutical dosage form design, excipients play a central role in delivering the drug in a safe and effective manner.…
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Toxicological assessment of Anionic Methacrylate Copolymer: I. Characterization, bioavailability and…
08. November 2016
Abstract
Anionic Methacrylate Copolymer (AMC) is a fully polymerized copolymer used in the pharmaceutical industry as an enteric/delayed-release coating to permit the pH-dependent release of active ingredients in the gastrointestinal tract from oral dosage forms.…
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Dual release and molecular mechanism of bilayered aceclofenac tablet using polymer mixture
Abstract
The objectives of the present study were to develop a controlled-release bilayered tablet of aceclofenac (AFN) 200 mg with dual release and to gain a mechanistic understanding of the enhanced sustained release capability achieved by utilizing a binary mixture of the sustained…
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Trehalose monooleate: a potential anti- aggregation agent for stabilization of proteins
18. October 2016
Protein aggregation is a major problem of therapeutic proteins because aggregation decreases their therapeutic activity, shelf life and induces immunogenicity. Stabilization against aggregation is commonly attained by addition of different excipients like sugars,…
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Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation,…
The purpose of this work was to increase the solubility and the dissolution rate of itraconazole, which was chosen as the model drug, by obtaining an amorphous solid dispersion by hot melt extrusion. Therefore, an initial preformulation study was conducted using differential scanning…
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Functionality of Benecel K4M/Carbopol 971P NF matrices in direct compression tablets for controlled…
Functionality of Benecel K4M/Carbopol 971P NF matrices in direct compression tablets for controlled release
The aim of this work is the assessment of the eventual enhancing effects of Carbopol 971P NF on the performance of Benecel K4M as a controlled release agent and its impact on other…
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PEO Hot Melt Extrudates for Controlled Drug Delivery: Importance of the Molecular Weight
26. September 2016
Abstract
Poly(ethylene oxide) (PEO)-based hot melt extrudates offer an interesting potential as oral controlled drug delivery systems and can provide additional advantages, such as reducing the risk of drug abuse. Different polymer molecular weight PEOs are…
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Characterization and quantification of pH sensitive polymers used in drug targeting by inverse-phase…
22. September 2016
Characterization and quantification of pH sensitive polymers used in drug targeting by inverse-phasegas chromatography and dynamicvapour sorption techniques
Surface energies and dynamic vapour sorption (DVS) plays an imparative role in drug polymer interaction in the…
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