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Polymers
Investigating the Use of Polymeric Binders in Twin Screw Melt Granulation Process for Improving…
Traditionally, the melt granulation for pharmaceutical products was performed at low temperature (<90°C) with high-shear granulators using low-melting waxy binders, and tablets produced using such granules were not amenable to large-scale manufacturing. The situation has changed in recent…
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SOLUBILITY AND PERMEATION STUDIES USING SOLUPLUS® AND HPMC WITH A BCS CLASS II AMORPHOUS DRUG
22. August 2016
Summary of the Master Thesis
Indomethacin (IND) is classified in class II of the Biopharmaceutics Classification System (BCS), meaning it exhibits good permeability, but poor solubility. By using the amorphous form of the drug higher apparent solubility can be…
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Merck Expands Excipients Portfolio, Adding Polymers for Sustained Release Injectables
Darmstadt, Germany, July 12, 2016 — Merck, a leading science and technology company, has entered into an agreement with PCAS S.A. (Longjumeau, France) to expand Merck’s excipients portfolio. Under the agreement, Merck will be the exclusive, global distributor of the Expansorb® line of biocompatible…
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Once-daily amoxicillin immediate- and extended-release bilayer tablets
Multilayer/bilayer tablets have been applied for the formulation of incompatible components for compound preparations, but more often they are used to modify drug release. The objective of this study was to explore the feasibility of developing, using a bilayer tablet strategy, an…
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Flow and compaction properties of hypromellose: new directly compressible versus the established…
26. April 2016
Context: Information about flow and compaction properties of hypromellose (HPMC) polymers is essential for technologists who are facing challenges regarding poor flow and compaction while developing new controlled release matrix tablets. There is a profound lack of…
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Formulation Development of Floating Microspheres of Cefditoren Pivoxel by 32 Factorial Design and in…
08. April 2016
Aim: The main objective of the present research work was to develop floating microspheres of cefditoren pivoxel (CP) to provide the delivery of the drug at a sustained rate.
Materials and Methods: Floating microspheres of CP were prepared by solvent evaporation…
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Polymeric microcontainers improve oral bioavailability of furosemide
03. April 2016
Microcontainers with an inner diameter of 223 μm are fabricated using the polymer SU-8, and evaluated in vitro, in situ and in vivo for their application as an advanced oral drug delivery system for the poorly water soluble drug furosemide. An amorphous sodium…
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Injection Molding as a One-Step Process for the Direct Production of Pharmaceutical Dosage Forms…
26. March 2016
The objective of the present study was to develop a one-step process for the production of tablets directly from primary powder by means of injection molding (IM), to create solid-dispersion based tablets. Fenofibrate was used as the model API, a polyvinyl…
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Formulation and evaluation of Thiocolchicoside Topical Gel by using different method
15. March 2016
Thiocolchicoside used for the effective treatment of muscle spasm, cramps, musculoskeletal and neuromuscular disorders. It is available in market in the form of capsules and injection. The major problem associated with thiocolchicoside is it's bioavailability which is…
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S-protected thiolated hydroxyethyl cellulose (HEC): novel mucoadhesive excipient with improved…
08. March 2016
The aim of this study was the design of novel S-protected thiolated hydroxyethyl cellulose (HEC) and the assessment of its mucoadhesive properties and biodegradability compared to the corresponding unmodified polymer. Thiolated HEC was S-protected via disulfide bond…
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