Browsing Category
Polymers
S-protected thiolated hydroxyethyl cellulose (HEC): novel mucoadhesive excipient with improved…
08. March 2016
The aim of this study was the design of novel S-protected thiolated hydroxyethyl cellulose (HEC) and the assessment of its mucoadhesive properties and biodegradability compared to the corresponding unmodified polymer. Thiolated HEC was S-protected via disulfide bond…
Read More...
Read More...
Development and Evaluation of Fast Dissolving Oral Film of Losartan Potassium
23. February 2016
Fast dissolving oral film of Losartan potassium were prepared and evaluated with an objective to rapid dissolution of drug and absorption which may produce the rapid onset of action in the treatment of hypertension and provides the convenient means of …
Read More...
Read More...
Design and Evaluation of Buccal Patch Containing Combination of Hydrochlorothiazide and Lisinopril
19. February 2016
Design and Evaluation of Buccal Patch Containing Combination of Hydrochlorothiazide and Lisinopril
Purpose: The objective of the present study was to formulate and evaluate buccal patches containing combination of lisinopril (LP) and hydrochlorothiazide (HCZ).…
Read More...
Read More...
Tragacanth as an oral peptide and protein delivery carrier: characterization and mucoadhesion
08. February 2016
Biopolymers such as tragacanth, an anionic polysaccharide gum, can be alternative polymeric carrier for physiologically important peptides and proteins. Characterization of tragacanth is thus essential for providing a foundation for possible applications.…
Read More...
Read More...
Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug…
05. February 2016
The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which…
Read More...
Read More...
The influence of hydrophylic polymers on the release rate of calcium dobesilate in hydrogel…
28. January 2016
A shortage of available experimental data exists in the available bibliography on the release rate of calcium dobesilate (CD) from hydrogel formulations. Thus, the aim of the study was to evaluate the effect of selected hydrophilic nonionic polymers and anionic…
Read More...
Read More...
Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl…
Read More...
Read More...
Extended-release venlafaxine pellets: scaling up – Poster Ashland AAPS 2014
06. December 2015
Introduction:
This study from Ashland was undertaken to investigeate the influence of coating process scale when applying an organic solvent based modified release coating to multiparticulates using a Wurster process.
Download the full poster here…
Read More...
Read More...
Melt pelletization of alginate: Effects of air pressurization on consolidation and drug release…
Microstructure consolidation of pellets is envisaged to enable a reduction of drug release in early dissolution phase. This study examines the effects of processing air pressure on drug release property of pellets and their mechanistic modifications on the matrices. The pellets were prepared using a…
Read More...
Read More...
Formulation Study of Chitosan Microparticles Loaded with Lactoferrin – Research Article
04. June 2015
Lactoferrin (LF) is known to show various useful biological features such as antimicrobial, antiviral, antitumor and anti-inflammatory effects. However, orally administered LF undergoes enzymatic degradation in the gastrointestinal tract, resulting in extensive…
Read More...
Read More...