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Polysorbates
Poly(caprolactone)/lignin-based 3D-printed dressings loaded with a novel combination of bioactive…
Curcumin (CUR) has been shown to possess significant anti-inflammatory properties and significant wound healing potential. Additionally, lignin (LIG) is a renewable biomacromolecule with well-known antioxidant and antimicrobial properties, which makes this biomacromolecule a good candidate to be…
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Formulation and evaluation of ocular self-nanoemulsifying drug delivery system of brimonidine…
The aim of the current study was to develop an ocular Self-nanoemulsifying drug delivery system (SNEDDS) loaded with Brimonidine tartrate (BRT) and evaluate its ex-vivo permeability. SNEDDS loaded with BRT were prepared by low energy method. Physicochemical properties, drug release, ex-vivo…
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Fabrication of Sustained Release Curcumin-Loaded Solid Lipid Nanoparticles (Cur-SLNs) as a Potential…
The goal of current research was to develop a new form of effective drug, curcumin-loaded solid lipid nanoparticles (Cur-SLNs) and test its efficacy in the treatment of lung cancer. Different batches of SLNs were prepared by the emulsification–ultrasonication method. For the optimization of…
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Stability of APIs in Super Refined PEG – Maximise the Performance of Your Active…
Discover the Benefits of Super Refined Excipients
Polyethylene glycols (PEGs) are excipients that are widely used in oral, parenteral and topical delivery dosage forms. Low molecular weight PEGs, such as PEG 300 and PEG 400 in particular, are used as solvents in concentrated formulations that are…
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Design, development and evaluation of self-microemulsifying drug delivery system of pazopanib for…
Pazopanib is the first-line treatment for patients with advanced or metastatic renal cell carcinoma. However, the commercially available preparation is characterized by low solubility, poor bioavailability and suboptimal therapeutic concentrations in majority of patients. The aim of this study was…
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Cationic Solid SMEDDS of Efavirenz for Improved Oral Delivery: Development by Central Composite…
Efavirenz (EFV) is an anti-HIV drug with high dose and 40% oral bioavailability (BA). The aim was to improve the bioavailability by designing cationic solid SMEDDS. Solubility data, ternary phase diagrams, and central composite design were employed in design. Globule size, TEM, DSC, and SEM studies…
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Formulation, development and characterization of ibuprofen microemulgel for arthritis
Objective: Microemulgel is composed of aqueous phase, lipophilic phase, along with surfactant and co-surfactant, a suitable gelling agent is also incorporated. The drug Ibuprofen is non-steroidal anti-inflammatory drug. Its oral administration associated with many GIT, hepatic and renal problems.…
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Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases
Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease of administration and convenience. However, it remains a…
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SARS-CoV-2 vaccine excipients polyethylene glycol and trometamol do not induce mast cell…
The development of vaccines against SARS-CoV2 brought about several challenges, including the management of hypersensitivity reactions to these formulations. The search for underlying mechanisms involved in these adverse events initially focused on excipients which may trigger mast cell activation…
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The Power of Excipient Purity in API Stability – Maximise the Performance of Your Active…
Discover the Benefits of Super Refined Excipients
Active Pharmaceutical Ingredient (API) stability is one of the most important factors in pharmaceutical formulation development. Degradation and instability are common problems that can lead to extended development timescales, additional…
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