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Polysorbates
The most recent advances in liquisolid technology: Perspectives in the pharmaceutical industry
Abstract
Hydrophobic drugs exhibit altered bioavailability and pose other challenges at an industrial level due to their poor solubility and dissolution rates. In addition, poor flowability, compressibility, complex dosing schedules, and light-sensitivity problems associated with hydrophobic…
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Liquisolids: A Modernistic approach in Drug Delivery System
Abstract
Liquisolid Technology aims to make drug entities more soluble that have low solubility and low permeability, through the cosolvency theory in a reasonably simple setup that doesn't require expensive technology. A non-volatile solvent is used to dissolve a medicine into molecular…
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Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of…
Solid lipid microparticles (SLMs) represent a promising approach for drug delivery in anti-acne applications. In this study, asiatic acid-loaded SLMs (AASLMs) were prepared by melt emulsification method in conjunction with freeze-drying. Comprehensive evaluations comprised particle size, %entrapment…
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Ternary solid dispersions of lacidipine: Enhancing dissolution and supersaturation maintenance…
The study aimed to address the challenges related to insufficient dissolution and maintenance of supersaturation in binary solid dispersions. Lacidipine, categorized as a BCS class II drug, was employed as the model drug. A systematic screening of excipients was conducted to determine the most…
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Simplex Lattice Design and Machine Learning Methods for the Optimization of Novel Microemulsion…
Novel p-coumaric acid microemulsion systems were developed to circumvent its absorption and bioavailability challenges. Simplex-lattice mixture design and machine learning methods were employed for optimization. Two optimized formulations were characterized using in vitro re-dispersibility and…
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SEPITRAP™ offers new possibilities for formulation and improving the bioavailability of active…
Description
SEPITRAP™ is a micro-encapsulated solubilizer in powder form designed to simplify the manufacturing of solid oral form drugs. It is manufactured by adsorption of the solubilizer in liquid form on a porous support.
SEPITRAP™ is both a solid solubilizer and a compression agent.…
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Fabrication of Orally Fast Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze…
Abstract
Introduction: The development of a novel dosage form for cannabis extract is necessary to improve drug delivery
and to also enhance patient convenience.
Methods: Orally fast disintegrating wafer tablets containing cannabis extract, which were prepared using the
freeze drying…
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Self-microemulsifying system of an ethanolic extract of Heliopsis longipes root for enhanced…
Abstract
Self-microemulsifying or self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS) are well known to improve the dissolution and increase the oral bioavailability of hydrophobic drugs, including herbal extracts. Organic extracts of Heliopsis longipes root and affinin, its main component,…
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Chitosan and Anionic Solubility Enhancer Sulfobutylether-β-Cyclodextrin-Based Nanoparticles as…
Abstract
Cataract surgery interventions are constantly increasing, particularly among adult and elderly patients. This type of surgery can lead to inflammatory states of the ocular anterior segment (AS), usually healed via postoperative treatment with dexamethasone (DEX)-containing eye drops. The…
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Third-Generation Solid Dispersion Through Lyophilization Enhanced Oral Bioavailability of…
Resveratrol (RES) is a biopharmaceutical classification system (BCS) class II compound with low solubility and high permeability. Several strategies have been explored to overcome the low bioavailability of RES, making the formation of solid dispersions (SDs) one of the most promising. This study…
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