Browsing Category
Polysorbates
Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment
This review evaluates the literature on nanoparticle-based drug delivery systems for cancer treatment and assesses their efficacy. Nanoparticles have shown potential for improving anticancer agent delivery, reducing systemic toxicity, and enhancing therapeutic outcomes. Extensive studies have shown…
Read More...
Read More...
Preparation and Characterization of Prednisolone Acetate Microemulsion for Ophthalmic Use
Abstract
Background: Prednisolone acetate is an ester form of prednisolone. It is used topically as an ophthalmic suspension to treat many inflammatory ocular conditions, where its absorption from suspension is highly variable and has poor dose accuracy.
Objectives: The main objective of this…
Read More...
Read More...
Enhanced Anti-Herpetic Activity of Valacyclovir Loaded in Sulfobutyl-ether-β-cyclodextrin-decorated…
Valacyclovir (VACV) was developed as a prodrug of the most common anti-herpetic drug Acyclovir (ACV), aiming to enhance its bioavailability. Nevertheless, prolonged VACV oral treatment may lead to the development of important side effects. Nanotechnology-based formulations for vaginal administration…
Read More...
Read More...
Influence of Poloxamer 188 on Anti-Inflammatory and Analgesic Effects of Diclofenac-loaded…
Abstract
In this study, a polymer-stabilized nanoemulsion (PNE) was developed to improve the inflammatory and analgesic activities of diclofenac (DA). DA-PNEs were prepared from sesame oil and poloxamer 188 (P188), polysorbate 80, and span 80 as emulsifiers and optimized by a systematic…
Read More...
Read More...
Structural modifications for the conversion of proteins and peptides into stable dried powder…
The drying of biomolecules into powdered formulations has become the main form of long-term product stabilisation, allowing for the delivery of safe and efficient medicines. Stability of proteins and peptides during the drying process is paramount for product quality. Drying macromolecules with an…
Read More...
Read More...
Tioconazole-Loaded Transethosomal Gel Using Box–Behnken Design for Topical Applications: In Vitro,…
Tioconazole (TCZ) is a broad-spectrum fungicidal BCS class II drug with reported activity against Candida albicans, dermatophytes, and certain Staphylococci bacteria. We report the use of TCZ-loaded transethosomes (TEs) to overcome the skin’s barrier function. TCZ-loaded TEs were fabricated by using…
Read More...
Read More...
Development of Osthole-Loaded Microemulsions as a Prospective Ocular Delivery System for the…
Osthole (OST), a natural coumarin compound, has shown a significant inhibitory effect on corneal neovascularization (CNV). But, its effect on treating CNV is restricted by its water insolubility. To overcome this limitation, an OST-loaded microemulsion (OST-ME) was created to improve the drug’s…
Read More...
Read More...
Formulation And Characterization Of Provesicular Based Drug Delivery System For Effective…
Oral intake of Itraconazole (ITZ) causes severe side effects in the gastrointestinal tract and has low bioavailability ~55%. Owing to these disadvantages, Transdermal drug delivery system (TDDS) of such antifungal agents can overcome such issues and can improve the efficacy and bioavailability. The…
Read More...
Read More...
Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient…
Objective
The primary objective of this study was to develop nanostructured lipid carriers of donepezil hydrochloride (DNZ HCl) for effective management of Alzheimer’s disease (AD).
Significance
Intranasal administration of DNZ NLC containing Nigella sativa (NS) oil as a liquid lipid may…
Read More...
Read More...
Development and Optimization of a Novel Lozenge Containing a Metronidazole-Peppermint Oil-Tranexamic…
In-depth studies on essential oil–based nanoemulsions (NEs) have centered on a variety of oral health issues. NEs improve the delivery of nonpolar active agents to sites and thereby boost the dissolution and distribution of the agents. Metronidazole-peppermint oil-tranexamic acid…
Read More...
Read More...