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Polyvinyl Alcohol – PVA
Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a…
The study aims to investigate the ability of lyophilized nasal inserts of nanosized atomoxetine HCl solid lipid nanoparticles (ATM-SLNs) to transport atomoxetine (ATM) directly to the brain and overcome the first-pass metabolism. In this case, 16 formulae of (ATM-SLNs) were prepared using hot melt…
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Selective laser sintering additive manufacturing of dosage forms: Effect of powder formulation and…
Large batches of placebo and drug-loaded solid dosage forms were successfully fabricated using selective laser sintering (SLS) 3D printing in this study. The tablet batches were prepared using either copovidone (N-vinyl-2-pyrrolidone and vinyl acetate, PVP/VA) or polyvinyl alcohol (PVA) and…
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Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement.…
Abstract
Introduction
Mucoadhesive drug delivery systems (MDDS) are specifically designed to interact and bind to the mucosal layer of the epithelium for localized, prolonged, and/or targeted drug delivery. Over the past 4 decades, several dosage forms have been developed for localized as…
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Polymeric Systems for the Controlled Release of Flavonoids
Flavonoids are natural compounds that are attracting great interest in the biomedical field thanks to the wide spectrum of their biological properties. Their employment as anticancer, anti-inflammatory, and antidiabetic drugs, as well as for many other pharmacological applications, is extensively…
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Multifunctional low temperature-cured PVA/PVP/citric acid-based hydrogel forming microarray patches:…
The characteristics of multifunctional polymeric hydrogel-forming microarray patches based on poly(vinyl alcohol)/poly(vinylpyrrolidone)/citric acid composite crosslinked at 80 °C were investigated. The swelling study showed that this composite possesses a higher swelling degree than the same…
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Use of polyvinyl alcohol (PVA) to overcome challenges in ophthalmic formulations
Successful ophthalmic drug formulations rely on the selection of the correct polymer to ensure the desired characteristics such as retention in the eye cavity and solubility. One example of such an excipient is polyvinyl alcohol (PVA) which offers many advantages for ophthalmic drug formulations…
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Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases
Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease of administration and convenience. However, it remains a…
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The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly…
Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioavailability. This work provides a comprehensive investigation…
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Recent approaches for enhancing the performance of dissolving microneedles in drug delivery…
Dissolving microneedles (dMNs) are promising versatile drug delivery systems for the transdermal delivery of numerous drugs, enabling their use in a wide range of biomedical and pharmaceutical applications. Being made of water-soluble polymers, dMNs own several advantages, including fast dissolution…
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Advances in Formulation and Manufacturing Strategies for the Delivery of Therapeutic Proteins and…
Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity to the site of action and reduced adverse effects resulting in increased use of these agents for medical treatments and therapies. Consequently, there is a need to formulate…
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