Polyvinyl Alcohol – PVA

Objective: Development and evaluation of bucco-adhesive films of Gliclazide for pediatric use. Methods: Sixteen films were formulated using a different combination of Gelatin, Hydroxy propyl methyl cellulose (HPMC), polyvinyl alcohol, Hydroxy propyl cellulose (HPC), chitosan, polyethylene glycol,…
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Abstract Dry eye disease (DED) is the most common clinical ocular surface disease. Given its multifactorial etiology, no consensus has been reached on the diagnosis criteria for dry eye disease. Topical drug administration remains the mainstay of treatment but is limited to the rapid clearance from…
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Two Polyvinyl Alcohol Grades Providing Excellent Performance for Solubility Enhancement and Stabilization Poor solubility of APIs is a critical challenge in drug development. One formulation technique to address this challenge is hot melt extrusion (HME). Mercks Parteck® MXP range of polymers…
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The current study intended to develop a new treatment of schizophrenia having a sustained release activity. Quetiapine fumarate (QF)-loaded polymer/lipid hybrid nanoparticulate systems of polycaprolactone (PCL) and Geleol™ were fabricated using polyvinyl alcohol (3% w/v). The proposed hybrid systems…
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Transepidermal microneedle-assisted drug delivery is an alternative approach that can improve the therapeutic permeability of the drug in the deeper layers of the skin. The project aims to check the effect of a microneedle roller on transepidermal delivery of Iloperiodone across the neonatal porcine…
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Ophthalmic drug formulations are growing in importance due to the increased prevalence of eye-related disorders such as diabetic retinopathy and macular degeneration.1 However, ocular drug delivery is challenging due to unique anatomical and physiological barriers such as pre-corneal loss factors…
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Abstract A solid lipid nanoparticle provides the opportunity of developing new therapies due to their unique size-dependent characteristics. They are a small particle that ranges between 1-100 nm in size. Lipid nanoparticles have risen in popularity in this context due to their widespread…
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The role of microneedle array patches (MAPs) and, in particular, dissolving MAPs in transdermal drug delivery has increased exponentially over the last decade. MAPs are able to form drug depots in the viable skin from where poorly soluble drugs dissolve in a long-acting fashion, showing promise in…
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Spray drying is a promising technology for drying lipid nanodispersions. These formulations can serve as carrier systems for poorly water-soluble active pharmaceutical ingredients (APIs) that are loaded into the lipid matrix to improve their bioavailability. Once the API-loaded nanocarriers have…
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The potential of the mucoadhesive film technology is hard to ignore, owing to perceived superior patient acceptability versus buccal tablets, and significant therapeutic opportunities compared to conventional oral drug delivery systems, especially for those who suffer from dysphagia. In spite of…
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