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Polyvinyl Alcohol – PVA
Commercially Available Enteric Empty Hard Capsules, Production Technology and Application
Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota…
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Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization…
BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon® VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ’s poor solubility. A novel strategy for…
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The role of hydrophilic/hydrophobic group ratio of polyvinyl alcohol on the miscibility of…
The miscibility of the therapeutic drug in the polymer matrix is the key to the successful design and development of orodispersible films (ODFs). In the present study, four hydrolyzed polyvinyl alcohols (PVAs) with identical polymerization degree were investigated as carriers for Amlodipine (AML)…
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Ophthalmics Process by Merck – Keep a close eye on quality and safety
Reduce risk and overcome challenges
Ophthalmic drugs pose special formulation challenges to manufacturers. In general, choosing the right processes and materials is important to ensure the required quality, drug tolerability and patient adherence. Formulators must pay attention to tonicity, pH,…
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Oral Disintegrating Tablets – see the solution landscape
Introduction
Oral disintegrating tablets (ODTs) are patient-centric drug delivery systems (for example, for pediatrics, geriatrics, and psychiatric patients with dysphagia) designed to increase patient compliance. ODTs are preferred to classic dosage forms (swallowable / chewable / suckable…
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Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances…
In this study, poly (lactic-co-glycolic) acid (PLGA) particles were synthesized and coated with chitosan. Three essential oil (EO) components (eugenol, linalool, and geraniol) were entrapped inside these PLGA particles by using the continuous flow-focusing microfluidic method and a partially…
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The clinical and translational prospects of microneedle devices, with a focus on insulin therapy for…
Abstract
Microneedles have the clinical advantage of being able to deliver complex drugs across the skin in a convenient and comfortable manner yet haven’t successfully transitioned to medical practice. Diabetes mellitus is a complicated disease, which is commonly treated with multiple daily…
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Development and Evaluation of Dissolving Microarray Patches for Co-administered and Repeated…
Purpose
Whilst significant progress has been made to defeat HIV infection, the efficacy of antiretroviral (ARV) therapy in the paediatric population is often hindered by poor adherence. Currently, two long-acting (LA) intramuscular injectable nanosuspensions of rilpivirine (RPV) and cabotegravir…
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Design and development of 3D-printed Bento Box model for controlled drug release of propranolol HCl…
The goal of this study was to develop a 3D-printed bento box model (3D-printed BB) with one or two chambers containing propranolol hydrochloride (PNL) as powder and matrix tablet for controlled drug release at varying times using United States Pharmacopeia (USP) dissolution guidelines. The…
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When coating runs smoothly – Parteck® COAT: Reduce your process time with an optimized polymer…
Our broad range of formulation products covers excipients for solid, semi-solid and liquid dosage forms for small and large molecules. Additionally, we offer a portfolio of drug delivery compounds (DDCs), as well as solutions for solubility enhancement and controlled release. Benefit from our…
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