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Polyvinyl Alcohol – PVA
Effect of carboxymethyl cellulose and polyvinyl alcohol on the cracking of particulate coating…
We investigated the effect of polymers on the cracking of particulate coating layers. Carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVA) were used as contrasting polymer additives due to their different surface charges and film characteristics. Drying stress that generates cracking in…
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Oral delivery of stem-cell-loaded hydrogel microcapsules restores gut inflammation and microbiota
Mesenchymal stem cells (MSCs) are an attractive candidate for the treatment of inflammatory bowel disease (IBD), but their poor delivery rate to an inflamed colon is a major factor hampering the clinical potential of stem cell therapies. Moreover, there remains a formidable hurdle to overcome with…
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Research progress of natural product-based nanomaterials for the treatment of inflammation-related…
Inflammatory diseases present with dysregulated inflammatory reactions and oxidative stress, resulting in heavy health-associated economic burden to society. Current mainstream therapies, including traditional therapies such as steroids, non-steroidal anti-inflammatory drugs (NSAIDs) and…
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Oral Thin-films from Design to Delivery: A Pharmaceutical Viewpoint
Stable drug-type tablets and capsules are painful to drink or chew for many pediatric and geriatric patients. Accurate dosing is also an issue for liquid orals (syrup, suspension, emulsion, and so on). Several fast-dissolving drug delivery systems have been designed to address these issues. One of…
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Aversion liquid-filled drug releasing capsule (3D-RECAL): A novel technology for the development of…
COVID19 has caused a significant socioeconomic burden worldwide. Opioid crisis was further intensified with the increasing number of opioid overdose/misuse related deaths in last two years. Abusers have adopted newer/efficient methods for manipulating and abusing commercial opioid formulations. Food…
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QBD approach for the development of hesperetin loaded colloidal nanosponges for sustained delivery:…
Hesperetin (HT) is a polyphenolic compound with anti-carcinogenic, tumor necrosis, and anti-oxidant properties. The present study reports the fabrication, optimization, and evaluation of HT-loaded nanosponges (HTN)- based gel (HTNG) for sustained anti-inflammatory effect. HTN formulation was…
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Cellulose nanofibers/PVA blend polymeric beads containing in-situ prepared magnetic nanorods as dye…
Magnetic beads were developed from polyvinyl alcohol and different amounts of cellulose nanofibers (CNF) by in-situ preparation of iron oxide nanoparticles in an alkaline aqueous medium at room temperature. The CNF were isolated from wheat straw, whereas the magnetic nanoparticles (MNPs) precursors…
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Dry Powder Formulation of Simvastatin Nanoparticles for Potential Application in Pulmonary Arterial…
It has been hypothesized that simvastatin could be used to treat pulmonary arterial hypertension (PAH). This study is intended to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation. Simvastatin nanoparticles were prepared via an emulsification and homogenization-extrusion…
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Optimization of a film coating formulation for high solid content application suitable for…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Preparation and Evaluation of Extended-Release Nanofibers Loaded with Pramipexole as a Novel Oral…
Purpose
Pramipexole (Prami) is renowned as one of the most widely used drugs in the treatment of Parkinson’s disease. This study aimed to prepare slow-release nanofibers of Prami to reduce (or control) the release rate of the drug from the formulation.
Methods
For this purpose, polyvinyl alcohol…
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