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Polyvinyl Alcohol – PVA
Fused Deposition Modeling as a Possible Approach for the Preparation of Orodispersible Tablets
Additive manufacturing technologies are considered as a potential way to support individualized pharmacotherapy due to the possibility of the production of small batches of customized tablets characterized by complex structures. We designed five different shapes and analyzed the effect of the…
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Development and analysis of a novel loading technique for FDM 3D printed systems: Microwave-assisted…
In this paper, we describe a modular post-printing loading protocol for a 3D printed gastro-retentive drug delivery system. Fused Deposition Modelling (FDM) 3D printing was exploited for the rapid prototyping of a modular floating system (caps-in-cap). Optimized models were produced as blank PVA …
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3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development,…
Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and…
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3D-Printed Coating of Extended-Release Matrix Tablets Effective Tool for Prevention of…
Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to be well-known and invariable under numerous conditions in order to prevent any uncontrolled drug release. Particularly important is the stability and invariability of…
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Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through…
Itraconazole (ITZ) is a class II drug according to the biopharmaceutical classification system. Its solubility is pH 3-dependent, and it is poorly water-soluble. Its pKa is 3.7, which makes it a weak base drug. The aim of this study was to prepare solid dispersion (SD) pellets to enhance the release…
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Design and optimization of process parameters of polyvinyl alcohol-graft-lactic acid films for…
The objective was to apply a simplex lattice design to determine the properties of polyvinyl alcohol-graft-lactic acid (PVA-g-LA) with different values for two independent variables: curing time (X1) and LA ratio (X2). Each independent variable was varied among three levels: –1, 0, and +1. Three…
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Quantification and characterization of water within drug-eluting beads
This work describes the analysis and characterisation of polyvinylalcohol (PVA)-based hydrogel polymer beads, specifically focussing on the quantitative and qualitative aspects of water within such beads in the absence and presence of three drugs; doxorubicin and irinotecan (already utilised as…
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Emulsion-electrospun polyvinyl alcohol nanofibers as a solid dispersion system to improve solubility…
We attempted to improve the solubility of poorly water-soluble drugs by preparing drug-loaded polyvinyl alcohol (PVA) nanofibers as a solid dispersion system via emulsion electrospinning. Probucol (PBC), a poorly water-soluble drug, was used as a model drug. Nanofibers were electrospun using an…
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Enhanced Supersaturation via Fusion-Assisted Amorphization during FDM 3D Printing of Crystalline…
Filaments loaded with griseofulvin (GF), a model poorly water-soluble drug, were prepared and used for 3D printing via fused deposition modeling (FDM). GF was selected due to its high melting temperature, enabling lower temperature hot-melt extrusion (HME) keeping GF largely crystalline in the…
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Impact of Formulation on the Quality and Stability of Freeze-dried Nanoparticles
Freeze-drying is an effective approach to improve the long-term stability of nanomedicines. Lyoprotectants are generally considered as requisite excipients to ensure that the quality of nanoparticles is maintained throughout the freeze-drying process. However, depending on the type of nanoparticles,…
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