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Polyvinyl Alcohol – PVA
The evaluation of the effect of different superdisintegrants on the drug release from FDM 3D printed…
Paracetamol-loaded tablets were printed by fused deposition modelling technique, using polyvinyl alcohol as a backbone polymer and Affinisol™ HPMC as a plasticizer in all formulations. Four different strategies were applied in order to accelerate the drug release from the tablets. First, different…
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Polymeric Nanoparticles and Chitosan Gel Loading Ketorolac Tromethamine to Alleviate Pain Associated…
This study describes the preparation and evaluation of two formulations, a hydrogel and a nanostructured system, containing ketorolac tromethamine as an anti-inflammatory agent for the local therapy against the inflammatory process derived from the surgical excision of Condyloma acuminata. Both…
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Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained…
Fungal infections affect millions of people globally and are often unreceptive to conventional topical or oral preparations because of low drug bioavailability at the infection site, lack of sustained therapeutic effect, and the development of drug resistance. Amphotericin B (AmB) is one of the most…
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Floating microspheres of Miglitol as gastro retentive drug delivery system: 32 full factorial design…
Background:
The goal of this study was to develop a gastro retentive floating drug delivery system that would improve site specific activity, patient compliance and therapeutic efficacy.
Methodology:
Floating microspheres of Miglitol were formulated by double emulsion method using ethyl cellulose…
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Contribution of Particle Design Research to the Development of Patient-Centric Dosage Forms
A variety of dosage forms have been developed in order to achieve effective and safe drug delivery in topical or systemic drug administrations. In this review, formulation research and process issues related to a popular oral dosage form, the tablet, are introduced. Research on oral dosage forms,…
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The interactions in ternary system made of xanthan gum, Carbopol 940 and anionic/nonionic surfactant
The development and optimization of systems consist of polymers and surfactants are strongly related to the presence of interactions between them. Therefore, the interpolymer complexes between biopolymer xanthan gum and synthetic polymer Carbopol 940 were investigated before and after the addition…
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Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based…
Betulinic acid (3β-Hydroxy-20(29)-lupaene-28-oic acid, BA) has excellent anti-cancer activity but poor solubility and low bioavailability. To improve the antitumor activity of BA, a polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol (PVCL–PVA–PEG) graft copolymer (Soluplus) encapsulated BA…
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Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing…
One of the challenges for developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,…
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Predicting Drug Release from 3D Printed Oral Medicines Based on the Surface Area to Volume Ratio of…
3D printing offers the advantage of being able to modify dosage form geometry, which can be exploited to modify release characteristics. In this study, we investigated the influence of the surface area to volume ratio (SA/V) to change and predict release profiles of 3D printed dosage forms.…
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Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and…
Lipid nanoparticles have been widely investigated for their use as either carriers for poorly water soluble actives or as (Pickering) emulsion stabilisers. Recent studies have suggested that the fabrication of lipid nanostructures that can display both these performances concurrently, can enable the…
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