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Polyvinyl Alcohol – PVA
Surfactants influence polymer nanoparticle fate within the brain
Drug delivery to the brain is limited by poor penetration of pharmaceutical agents across the blood-brain barrier (BBB), within the brain parenchyma, and into specific cells of interest. Nanotechnology can overcome these barriers, but its ability to do so is dependent on nanoparticle…
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Comparison of Three Different Aqueous Microenvironments for Enhancing Oral Bioavailability of…
Background: The purpose of this study was to screen various drug delivery systems for improving the aqueous solubility and oral bioavailability of sildenafil. Three representative techniques, solid self-nanoemulsifying drug delivery systems (SNEDDS), amorphous microspheres and crystalline…
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Statistical design of experiment-based formulation development and optimization of 3D printed oral…
Purpose
Producing several controlled- release 3D printed tablets from polymer blends with the required target product profile has been a challenge. Thus, experimental design could be applied to rationally explore the impact of the formulation excipients on drug release.
Methods
The optimization…
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Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun…
Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose,…
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Theoretical and experimental validation of praziquantel with different polymers for selection of an…
The selection of an appropriate matrix for the preparation of amorphous extrudate in hot-melt extrusion (HME) deals with the study of various solid-state properties of drugs and polymers. Therefore, it is necessary to have an appropriate knowledge of drug-polymer miscibility, the interaction between…
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3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs
Fused deposition modelling (FDM) is the most extensively employed 3D-printing technique used in pharmaceutical applications, and offers fast and facile formulation development of personalized dosage forms.
In the present study, mesoporous materials were incorporated into a thermoplastic filament…
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Fused deposition modeling (FDM)-mediated 3D-printed mouth-dissolving wafers loaded with…
Localized delivery of drugs or nanoparticles for oral cancer is always preferred. Additive manufacturing (AM)-driven 3D-printed wafers to deliver nanoparticles offers a new dimension to the cutting-edge delivery perspective. Nanostructured lipid carriers (NLCs) were loaded inside 3D wafers, printed…
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Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed…
Although hot melt extrusion (HME) has been used in combination with fused deposition modelling (FDM) three-dimensional printing (3DP), suitable feedstock materials such as polymeric filaments with optimum properties are still limited. In this study, various release modifying excipients, namely,…
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The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using…
In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated. The drug–polymer combinations were studied with regard to the influence of (i) the physicochemical properties of the…
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Shaping the Future of Formulation Development with Melt-based 3D Printing Technologies
Three-dimensional (3D) printing is a powerful technology that has wide-ranging applications, including many in the pharmaceutical industry. Among the approaches that are being explored in the production of pharmaceutical dosage forms powder-based systems which utilize either drop-on-powder or…
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