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Polyvinyl Alcohol – PVA
New Opportunities for Oral Sustained Release Formulations with Polyvinyl Alcohol
Achieving the appropriate release kinetics for an active pharmaceutical ingredient (API) is essential to ensure success of the therapeutic. For example, for sustained release formulations, a consistent API dose over a prolonged period ensures that levels in the blood plasma remain within the…
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Nanostructured micronized solid dispersion of crystalline-amorphous metronidazole embedded in…
In this study metronidazole drug was encapsulated by hydroxypropyl methylcellulose and polyvinylpyrrolidone polymers from solutions using nano spray drying technology. The influence of the process parameters and formulation variables were investigated on product morhology and structure, production…
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Functionality and Acceptance of the EsoCap System – A Novel Film-Based Drug Delivery…
There are no methods for specific local application of active substances to the mucosa of the esophagus to treat eosinophilic esophagitis or other esophageal diseases. This publication describes the principal in vivo functionality and acceptance of a novel modular drug delivery concept, called…
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Polyvinyl Alcohol/Chitosan Single-Layered and Polyvinyl Alcohol/Chitosan/Eudragit RL100…
A novel nanofiber insert was prepared with a modified electrospinning method to enhance the ocular residence time of ofloxacin (OFX) and to provide a sustained release pattern by covering hydrophilic polymers, chitosan/polyvinyl alcohol (CS/PVA) nanofibers, with a hydrophobic polymer, Eudragit RL100…
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The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of…
The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting…
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Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend…
In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5–10.0 wt% within the films. The inclusion of COS added a brown hue to the films.
FTIR spectroscopy revealed that…
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Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and…
Apremilast (APST) is an effective inhibitor of phosphodieasterase 4 (PDE4) which is the first oral drug for the treatment of adult patients with active psoriatic arthritis. However, Apremilast’s low solubility restricts its dissolution and bioavailability. In this study, APST solid dispersion with…
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Enhance API solubility. Achieve stable, high drug loads – with Parteck® MXP
Poor solubility of APIs is a critical challenge in drug development. One formulation technique to increase solubility and, consequently, improve bioavailability of drugs is hot melt extrusion (HME). With this technology, the API is dispersed into a polymer matrix to form an amorphous solid…
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Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for…
The present work aimed to formulate intranasal insulin fast-dissolving films for treatment of anosmia in patients post COVID-19 infection. Variant films were prepared employing the casting method and using hydroxypropyl methyl cellulose and polyvinyl alcohol. The formulated films were investigated…
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Polymeric Drug Delivery Systems by Additive Manufacturing
Additive manufacturing (AM) is gaining interests in drug delivery applications, offering innovative opportunities for the design and development of systems with complex geometry and programmed controlled release profile. In addition, polymer-based drug delivery systems can improve drug safety and…
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