Browsing Category
Polyvinyl Alcohol – PVA
Impact of co-processed excipient particles solidity and circularity on critical quality attributes…
The selection of appropriate functional co-processed excipient (CPE) is a crucial stage in orodispersible minitablets (ODMTs) development. This paper aimed to identify the most important morphological attributes influencing the flowability and homogeneity of powder mixtures and minitablets final…
Read More...
Read More...
Garcinol Encapsulated Ph-Sensitive Biodegradable Nanoparticles: A Novel Therapeutic Strategy for the…
The emergence of pH-sensitive nanoscale particles is beneficial due to their ability to only release cargo in a colonic pH environment, which helps to directly target inflamed tissues in inflammatory bowel disease (IBD). Hence, we have designed the formulation of pH-sensitive biodegradable garcinol…
Read More...
Read More...
Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation…
Three-dimensional printing (3D-printing) is a technology that prints the products layer-by-layer, in which materials are deposited according to the digital model designed by computer aided design (CAD) software. This technology has competitive advantages regarding product design complexity, product…
Read More...
Read More...
The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing…
Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer…
Read More...
Read More...
Evaluation of polymer choice on immunogenicity of chitosan coated PLGA NPs with surface-adsorbed…
Polymeric nanoparticles (NPs) are recognized as potential delivery vehicles for vaccines. PLGA is a biocompatible polymer synonymous with polymeric NPs, which can be coated with other polymers such as chitosan that has intrinsic adjuvant properties as well as mucoadhesive properties. Numerous…
Read More...
Read More...
3DP Printing of Oral Solid Formulations: A Systematic Review
Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has a broad range of applications. One of the most developed, it is the manufacture of oral solid dosage and the four 3DP techniques which have been more used for their…
Read More...
Read More...
Investigations of process parameters during dissolution studies of drug loaded 3D printed tablets
The present research paper attempts to study the effect of different process parameters on the dissolution rate during 3D printed tablets. Three-dimensional printing has the potential of serving tailored made tablets to cater personalized drug delivery systems.
Fluorescein loaded PVA filaments…
Read More...
Read More...
Generation of Ophthalmic Nanosuspension of Prednisolone Acetate Using a Novel Technology
Purpose
Prednisolone Acetate (PAC) is currently marketed as micronized ophthalmic suspension. The microsuspension has poor dose accuracy and efficacy due to aggregation, slow dissolution rate and limited corneal residence. The ophthalmic nanosuspension of PAC shall show enhanced solubility,…
Read More...
Read More...
Exploring the Interplay between Drug Release and Targeting of Lipid-Like Polymer Nanoparticles…
Targeted delivery of doxorubicin still poses a challenge with regards to the quantities reaching the target site as well as the specificity of the uptake. In the present approach, two colloidal nanocarrier systems, NanoCore-6.4 and NanoCore-7.4, loaded with doxorubicin and characterized by different…
Read More...
Read More...
Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation…
The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely on a scientific approach to enable efficient…
Read More...
Read More...