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Polyvinyl Alcohol – PVA
I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets
3D printing (3DP) in the pharmaceutical field is a disruptive technology that allows the preparation of personalised medicines at the point of dispensing. The paediatric population presents a variety of pharmaceutical formulation challenges such as dose flexibility, patient compliance, taste masking…
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The progress on sulfhydryl modified polymers with regard to synthesis, characterization and…
The concepts of mucoadhesion and mucoadhesive polymers were introduced in the 20th century, leading to several advantages. These included enhanced drug absorption and extended residence at specific site of action. Polymeric excipients underwent chemical modification with sulfhydryl groups on the…
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Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines
Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising solution to customize oral drug delivery has been found in…
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Polymeric Inserts Containing Eudragit® L100 Nanoparticle for Improved Ocular Delivery of…
Polymeric inserts containing azithromycin-loaded Eudragit® L100 nanoparticles were developed to sustain the drug release and enhance its ocular performance. The solvent diffusion technique was employed to prepare nanoparticles. The developed nanoparticles (NPs) were fully characterized and…
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Creation of Filaments for 3D Printing via Hot Melt Extrusion: Evaluating Different Downstream…
Purpose: For several years now 3D printing technology has been gaining increasing attention within the pharmaceutical industry. The number of publications is rapidly increasing. One promising 3D printing technology is the fused deposition modeling where a polymer strand is heated and extruded…
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Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison…
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are most common.…
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Towards a Continuous Manufacturing Process of Protein-Loaded Polymeric Nanoparticle Powders
To develop a scalable and efficient process suitable for the continuous manufacturing of poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing ovalbumin as the model protein. PLGA nanoparticles were prepared using a double emulsification spray-drying method. Emulsions were prepared using a…
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Abuse deterrent immediate release film technology (ADRIFT): A novel bilayer film technology for…
Prescription opioid abuse also known as opioid epidemic has been an ever-growing problem in the United States. It has been associated with numerous emergencies and mortality with significant burden on healthcare system. Amongst various approaches proposed by FDA, development of an abuse deterrent…
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3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted…
The establishment of 3D-printing as manufacturing process for oral solid dosage forms enables new options for the individualized medicine.
The aim of this work was to develop a novel drug-printing model using pressure-assisted microsyringe (PAM) technology, which allows the precise dispensing of…
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Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA)…
This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its…
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