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Polyvinyl Alcohol – PVA
Synthetic polymers for Microneedle synthesis: From Then to Now
Considering microneedles (MNs) as transdermal drug delivery tools is driven by some crucial factors among which easy handling, simple administration and better patient compliance are primary. Achievable tailored microneedle production allowing encapsulation of range of pharmaceuticals and…
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Mechanical Characteristics of Orally Disintegrating Films: Comparison of Folding Endurance and…
The tensile test is the most widely used method for testing the mechanical characteristics of orally disintegrating films (ODFs). The other available test is the folding endurance (FE) test, which is more suitable for clarifying the actual strength during the manufacturing and dosing. However, the…
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β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential…
Highlights
• β-cyclodextrin polymer showed 3–4 folds higher saturation solubility of Ebselen.
• β-cyclodextrin polymer was safer on HeLa cells compared to monomeric cyclodextrin.
• EβpolySol film rapidly disintegrated and immediately released EB in vaginal fluid.
• EβpolySol film…
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Development of an abuse deterrent formulation using hot melt extrusion – Thesis
In recent years prescription drug diversion, misuse, abuse represent a growing problem for the United States. Oral ingestion, snorting, injection are most commonly employed routes of abuse. To circumvent this problem hot melt extrusion (HME) was employed to prepare abuse deterrent formulation (ADF).…
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Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain drawbacks such as low tablet hardness and poor compressibility. The…
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Design, fabrication and characterisation of drug-loaded vaginal films: State-of-the-art
Highlights
• Film technology provides platforms adaptable to the desired drug release profile.
• Several natural and synthetic polymers have been considered to obtain vaginal films.
• Plasticisers and other excipients allow modifying the relevant properties of films.
• Solvent…
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Evaluating the suitability of a pH-dependent pore former in a sustained release film-coating…
Since the development of polymers for enteric coating in the late 1950’s, numerous investigations have illustrated the application of these functional excipients such as poly(methacrylic acid-co-ethyl acrylate). Also mixtures with other polymers like poly(vinyl acetate) have already been well…
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Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics
Three-dimensional (3D) printing offers the greatest potential to revolutionize the future of pharmaceutical manufacturing by overcoming challenges of conventional pharmaceutical operations and focusing design and production of dosage forms on the patient’s needs. Of the many technologies…
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Nanoprecipitation: Applications for Entrapping Active Molecules of Interest in Pharmaceutics
Nanoprecipitation technique, also named solvent injection, spontaneous emulsification, solvent displacement, solvent diffusion, interfacial deposition, mixing-induced nanoprecipitation, or flash nanoprecipitation, is recognized as a useful and versatile strategy for trapping active molecules on the…
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Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally…
Orally disintegrating tablets (ODTs) manufactured by freeze-drying, also called oral lyophilizates, are a patient-centred dosage form. They possess ultra-fast disintegration dynamics, have acceptable mechanical strength and have a smooth mouth texture. In this study, polyvinyl alcohol (PVA) was…
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