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Polyvinyl Alcohol – PVA
The EsoCap-system – An innovative platform to drug targeting in the esophagus
For the therapy of esophageal diseases such as eosinophilic esophagitis, there are no possibilities of local targeted therapy. This publication describes a novel, innovative drug delivery concept, that enables a targeted, long-lasting administration of drug substances to the esophageal mucosa. In…
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Progress in the design and development of “fast-dissolving” electrospun nanofibers based drug…
Electrospinning has emerged as most viable approach for the fabrication of nanofibers with several beneficial features that are essential to various applications ranging from environment to biomedicine. The electrospun nanofiber based drug delivery systems have shown tremendous advancements over the…
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A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal…
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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it dicult to achieve therapeutic levels…
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Conversion of indomethacin nanosuspensions into solid dosage forms via fluid bed granulation and…
Preparation of pharmaceutical nanosuspensions is a popular technique to increase the dissolution velocity of poorly water-soluble drugs. Subsequent drying into a compaction-ready powder or granule is a critical process due to possible adverse solid characteristics and the risk of growth of…
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Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based…
Highlights
Novel hydrogel-forming microneedles were produced.
Their physicochemical properties were promising.
Methotrexate was successfully delivered in vitro and in vivo.
Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic…
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Mechanodegradation of polymers: a limiting factor of mechanochemical activation in the production of…
In this study we report on the influence of mechanochemical activation on the chemical stability of amorphous solid dispersions made up of indomethacin and HPMC, PVP, PVPVA or Soluplus®. In agreement with our recently published work, all applied carriers were found to be prone to chemical…
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Temperature and Solvent Facilitated Extrusion Based 3D Printing for Pharmaceuticals
On demand manufacturing of patient-specific oral doses provides significant advantages to patients and healthcare staff. Several 3D printing (3DP) technologies have been proposed as a potential digital alternative to conventional manufacturing of oral tablets. For additive manufacturing approach to…
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Oral Fixed-Dose Combination Pharmaceutical Products: Industrial Manufacturing Versus Personalized 3D…
Fixed-dose combination (FDC) products containing at least two different active pharmaceutical ingredients are designed to treat more effectively different pathologies as they have demonstrated to enhance patient compliance. However, the combination of multiple drugs within the same dosage form can…
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Human mouthfeel panel investigating the acceptability of electrospun and solvent cast orodispersible…
A human panel study was performed to investigate the acceptability of orodispersible electrospun and solvent cast films. 50 healthy volunteers took two drug-free samples of polyvinyl alcohol films prepared by the two methods. On a 5-point hedonic scale, the volunteers assessed the films’ perceived…
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