Quality by design (QbD) can also contribute to design, manufacturing, and producing highly finished goods. To better explain the manufacturing processes, the FDA focused QbD in the healthcare industry, based on a comprehensive understanding of how technology and design parameters affect the quality… Read More...
In present work, a film forming gel (FFG) was developed through ingenious amalgamation of polymers: Pullulan, Terminalia catappa and Carbopol®971P ® for cutaneous delivery of clotrimazole (CTZ) employing D-optimal mixture design. The developed FFG possess pseudoplastic, viscoelastic, thixotropic… Read More...
During wet granulation, the sample can be exposed to considerable mechanical effects, moisture content and elevated temperatures, and during high-shear granulation the impeller and chopper speeds can induce elevated temperatures and influence the parameters of the products.
Highlights… Read More...
In the manufacturing of pharmaceutical Oral Solid Dosage (OSD) forms, Particle Size Distribution (PSD) and Tensile Strength (TS) are common in-process tests that are controlled in order to achieve the quality targets of the end-product. The Quality by Design (QbD) concept elaborates process… Read More...
In this paper we present a thorough description of the digital twin development for a continuous pharmaceutical powder blending process in accordance with the Process Analytical Technologies (PAT) and Quality by Design (QbD) guidelines. A low-dosage system of caffeine active pharmaceutical… Read More...
Quercetin (QCT) is an effective antioxidant, antifibrotic and wound healing agent. Silver nanoparticles (AgNPs) are an effective antimicrobial and wound healing agent and considered as gold standard for wound treatment especially diabetic and burn wounds. The present study aimed to investigate QCT… Read More...
Diazepam is commonly used in the management of epileptic seizures, although it has limitations that can be overcome by using formulations that are easier to administer and capable of directing the drug to the brain. In this field, it has been reported that the use of nanostructured lipid carriers… Read More...
This study aimed to design and characterize Tofacitinib (TF)-loaded lyotropic liquid crystalline nanoparticles (TF-LCNP) gel using quality by design-driven approach to enhance the skin delivery of TF. The present work investigated the impact of two different liquid lipids on different critical… Read More...
Background: Multiple dosing is required for bosentan in order to achieve steady-state concentration. Hence formulating bosentan controlled release formulation could be an approach to solve this issue.
Objective: The objective is to develop floating multiple unit minitablets of bosentan using the… Read More...