Browsing Category
Quality by Design (QbD)
Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical…
The present study is concerned with the QbD-based design and development of luliconazole-loaded nanostructured lipid carriers (NLCs) hydrogel for enhanced skin retention and permeation. The NLCs formulation was optimized employing a 3-factor, 3-level Box-Behnken design. The effect of formulation…
Read More...
Read More...
Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability…
Despite significant advances in the research domain of continuous twin screw granulation, limited information is currently available on the impact of raw material properties, especially considering batch-to-batch variability. The importance of raw material variability and subsequent mitigation of…
Read More...
Read More...
Tailoring immediate release FDM 3D printed tablets using a Quality by Design (QbD) approach
The aims of this work were to produce immediate release printed tablets using fused deposition modelling (FDM) technique and to systematically explore the effects of different compositions on drug release by Quality by Design approach. Screening studies of various drug loadings and excipients were…
Read More...
Read More...
Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet
The aim of this study was to develop immediate-release oral rabeprazole sodium tablets with rapid efficacy and gastric stability for the treatment of gastroesophageal reflux disease. Rabeprazole sodium is a commonly prescribed proton pump inhibitor; however, it is extremely unstable and degrades in…
Read More...
Read More...
In Situ-Forming Microparticles for Controlled Release of Rivastigmine: In Vitro Optimization and In…
In this work, sucrose acetate isobutyrate (SAIB) and polylactic co-glycolic acid (PLGA) were used alone or in combination as a matrix-former (MF) to prepare long-acting injectable rivastigmine (RV) in situ-forming microparticles (ISM). RV-ISM were prepared by the emulsification of an internal phase,…
Read More...
Read More...
The evaluation of dynamic compaction analysis as a QbD tool for paediatric orodispersible mini…
The formulation of orodispersible minitablets (ODMTs) usually targets the disintegration time and mechanical strength, but should also consider a series of technological issues related to powder flow and compression behaviour. In this regard, the present study aimed to evaluate the contribution of…
Read More...
Read More...
Tailored granule properties using 3D printed screw geometries in twin screw granulation
Twin screw granulation is becoming increasingly relevant due to its compact size, continuous and robust mode of operation, customizable design, and flexible production capacity. This work describes the experimental study undertaken to understand the dependence of granule properties on the screw…
Read More...
Read More...
Application of 3D printing technology and quality by design approach for development of…
Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult formulations, but medication errors can result in suboptimal efficacy…
Read More...
Read More...
Developing a quality by design approach to model tablet dissolution testing: an industrial case…
09. November 2017
This study applied the concept of Quality by Design (QbD) to tablet dissolution. Its goal was to propose a quality control strategy to model dissolution testing of solid oral dose products according to International Conference on Harmonization…
Read More...
Read More...
Identifying overarching excipient properties towards an in-depth understanding of process and…
20. February 2017
Abstract
The overall objective of this work is to understand how excipient characteristics influence the process and product performance for a continuous twin-screw wet granulation process. The knowledge gained through this study is intended to be used for a Quality…
Read More...
Read More...