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Roller Compaction
Analysis of the impact of material properties on tabletability by principal component analysis and…
Principal component analysis (PCA) and partial least squares regression (PLS) were combined in this study to identify key material descriptors determining tabletability in direct compression and roller compaction. An extensive material library including 119 material descriptors and tablet tensile…
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A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction…
Abstract
This research investigates the modeling of the pharmaceutical roller compaction process, focusing on the application of the Johanson model and the impact of varying roll speeds from 1 to 15 RPM on predictive accuracy of ribbon solid fraction. The classical Johanson’s model was integrated…
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The influence of milling of ribbons on selected granule quality attributes and carvedilol release…
Abstract
Roller compaction is gaining importance in the pharmaceutical industry. This study evaluates the impact of ribbon milling conditions on properties of granules and compression mixtures and on drug release from hypromellose-based matrix tablets prepared with two different fillers. In the…
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Determining the Impact of Roller Compaction Processing Conditions on Granulate and API Properties:…
Previous work demonstrated that roller compaction of a 40%w/w theophylline–loaded formulation resulted in granulate consisting of un-compacted fractions which were shown to constitute between 34 and 48%v/v of the granulate dependent on processing conditions. The active pharmaceutical ingredient…
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Challenges encountered in the transfer of atorvastatin tablet manufacturing – commercial…
As is the case with batch-based tableting processes, continuous tablet manufacturing can be conducted by direct compression or with a granulation step such as dry or wet granulation included in the production procedure. In this work, continuous manufacturing tests were performed with a commercial…
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From Screening to Downstreaming – 4th Seminar on Amorphous Solid Dispersion
See the 4th Seminar on Amorphous Solid Dispersion.
As technology provider in the field of ASD, Shin-Etsu together with the partners Alexanderwerk, Frewitt, PROCEPT and Thermo Fisher Scientific, will share latest insights of ASD development steps ranging from initial screening phase up to downstream…
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Combined DEM and Johanson model for ribbon density prediction in a roller compactor
Abstract
Johanson (1965) developed a one-dimensional model for the stress acting on the powder in between the rolls of a roller compactor. Limited work has been performed regarding estimation of inlet stress; a parameter required for the estimation of ribbon density in a roller compactor. Due to…
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Effect of roll compaction pressure on the properties of high drug-loaded piracetam granules and…
Objective
The aim of this study was to use an alternative granulation technique, solventless roll compaction, and to investigate the effect of the roll compaction pressure on the properties of granules and high-drug-loaded (80%, w/w) immediate release piracetam tablets.
Significance…
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A novel approach to minimize loss of compactibility in a dry granulation process using…
Dry granulation via roller compaction is increasingly being used as granulation method for the production of oral solid dosage forms. Advantages of roller compaction include a simplified process compared to wet granulation and the inherently continuous nature of the process. A common problem of dry…
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Improving Process Understanding in Roll Compaction
Roll compaction/ dry granulation is gaining importance. Numerous papers have been published and many attempts to model the process are available in the meantime. Johanson published a model in 1965, which is the basis for many further modifications until today. The aim of the paper is to improve…
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