Browsing Category
Roller Compaction
A Multi-variate Mathematical Model for Simulating the Granule Size Distribution in Roller…
Granule size distribution (GSD) is one of the critical quality attributes in the roller compaction (RC) process. Determination of GSD for newly developed pharmaceutical compounds with unknown ribbon breakage behaviors at the RC milling step requires a quantitative insight into process parameters and…
Read More...
Read More...
Compaction behavior of isomalt after roll compaction
Isomalt is a polyol derived from sucrose. Advantages of this excipient are its sweet taste, which is supposed to allow taste masking, the low glycemic and insulinemic response (Petzoldt, 1982), and the ability to be compacted directly. With regard to infantile patients, also the lack of…
Read More...
Read More...
A Mathematical Approach to Consider Solid Compressibility in the Compression of Pharmaceutical…
In-die compression analysis is an effective method for the characterization of powder compressibility. However, physically unreasonable apparent solid fractions above one or apparent in-die porosities below zero are often calculated for higher compression stresses.
One important reason for this…
Read More...
Read More...
An evaluation of the Johanson model for roller compaction process development for a high dose API
Roller compaction (RC) is a dry granulation technique applied to improve the flow and compressibility of drug formulations. RC implementation for high drug load formulations can be challenging due to flow issues and a high consumption of active pharmaceutical ingredient (API) for robust process…
Read More...
Read More...