A decrease in the drug release rate over time typically affects the performance of hydrophilic matrices for oral prolonged release. To address such an issue, a Non-Uniform Drug Distribution Matrix (NUDDMat) based on hypromellose was…

One of the major challenges for modern formulation development is the increasing number of poorly water-soluble drugs. A common formulation approach to improve the solubility of those poorly soluble active ingredients is to formulate them…

Damage to the drug diffusion coat barrier of controlled release pellets by the compaction force when preparing multiple-unit pellet system tablets is a major concern. Previous studies have shown that pellets located at the tablet axial…

Traditional dosage forms of dexibuprofen extremely limit their clinical applications because of the bitter taste and the frequent drug administration caused by the relatively short half-life of the drug. This study aims to design novel…

The general aim of this paper is to study the coating strength of different composite powders with an experimental approach based on mixing energy descriptors derived from linear velocity at the end of paddles. The chosen system is Cellets…

Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at…

In this era of modernization and hectic lifestyles, consumers demand functional foods providing nutrients with physiological and health benefits. Probiotics belong to this in-demand category of functional and nutraceutical foods.…

An optical method of experimentally quantifying the coating progress in a laboratory prismatic spouted bed is presented. Microcrystalline cellulose particles (Cellets) with size dp = 0.57 mm are used as core material. Waterborne coating…

Modified-release oral dosage forms are commonly used in pharmaceutics to delay or sustain the release of drugs. Nowadays, they are only marketed as solid dosage forms such as capsules or tablets. Therefore, the development of a liquid…