Semi-Solids

With the ability to fabricate personalized dosage forms and considerably shorter manufacturing time, semisolid extrusion (SSE) 3D printing has rapidly grown in popularity in recent years as a novel, versatile manufacturing method that powers a wide range of applications in the pharmaceutical field.…
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Topical drug delivery is the delivery of drugs anywhere in the body through skin, vaginal, ophthalmic and rectal routes. Drugs may be given for localized or systemic effects. Topical formulations with varying physicochemical properties, such as solid, semisolid, or liquid, can be developed. The…
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A Quality by Design approach was taken to assess the influence of several formulation parameters on critical quality attributes of liquisolid pellets (LPs) obtained by extrusion-spheronization. Two mixture experimental designs were used, one for each of the non-volatile solvents (NVS) studied:…
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Achieving drug delivery at the ocular level encounters many challenges and obstacles. In situ gelling delivery systems are now widely used for topical ocular administration and recognized as a promising strategy to improve the treatment of a wide range of ocular diseases. The present work…
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Topical formulations may be used to deliver active pharmaceutical ingredients (APIs) to or through the skin. These formulations typically possess a relatively soft, spreadable consistency and are often formulated as either water-in-oil or oil-in-water emulsions. BASF offers an unparalleled…
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Calcium alginate beads loaded with Mg(OH)2 improve L. casei viability under simulated gastric condition Alginate beads are commonly used for protection of probiotics against adverse environmental conditions. However, alginate beads are unable to provide complete cell viability under stringent…
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If you need technical information and practical tips to formulate with your lipid excipients, Gattefossé has prepared different case studies for download after registration. How to obtain sustained release tablets of metformin hydrochloride by direct compression? The aim was to develop dual SR…
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Implication of Quantitative Selection of Each Excipient in Product Development Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Carbopol® 971 and poly(2-ethyl-2-oxazoline) form hydrogen-bonded interpolymer complexes in aqueous solutions and their complexation is strongly dependent on solution pH. This work investigated the complexation between these polymers in aqueous solutions. The compositions of interpolymer complexes as…
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A series of epichlorohydrin-couple-linked cellulose-gelatin composite films (ECGF) was fabricated in NaOH/urea aqueous solution using a process involving homogenous blending, coupling, dialysis, self-dispersion, microgel solution casting, and evaporation. Their structure and properties were…
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