Seppic
An Air Liquide Healthcare company, subsidiary of the Air Liquide group, Seppic has been designing, manufacturing, and marketing unique ingredients for over 75 years. These ingredients are used by consumers, patients, and professionals for Pharmaceutical, Nutraceutical and Beauty markets.
At Seppic, being experts in formulation, polymers, surfactants, and emulsions, we offer innovative problem solving excipients and vaccine adjuvants for dermo-pharmaceutical, injectable, oral applications, for human and animal health. Our premium excipients and technological expertise allows us to be a sustainable partner and also assist our customers in their development projects.
Excipients for each administration route Oral Route
Seppic offers a wide range of excipients suitable for the oral route, whether dry (tablets, capsules, powders) or liquid (syrups, gels). Our excipients can be used to improve active ingredient bioavailability, formulation stability, taste masking and therapeutic adherence, regardless of the active ingredients or forms.
Film coating agents for tablet medications
With 35 years of experience, Seppic is a recognised expert in ready-to-use coating and offers a wide range of functional, titanium free, and aesthetics ready-to-use film-coating excipients. Seppic also provides on-site assistance to help its customers successfully perform scale-up, to solve coating issues and to give specific technical advice, and provides assistance on any regulatory questions. The coating products offered by Seppic provide various benefits:
- Protect cores from external aggression with a physical barrier
- Protect hygroscopic cores from humidity
- Modulate the release of the active ingredient
- Color tablets to facilitate identification
- Improve therapeutic adherence by facilitating drug intake (swallowing) and by masking the intrinsic active ingredient characteristics (taste, color, odor…)
Discover Seppic’s range of efficient coating solutions
1. Functional ready-to-use film-coating products
To protect your cores against moisture
Moisture Protection Coating: Range of optimized immediate-release film-coating agents with multiple choice of moisture protection levels
Sepifilm™ LP range
For the optimal protection of active ingredients and sensitive cores. Due to its unique composition and granular form, Sepifilm™ LP offers many advantages: process-related in terms of ease of use, effective moisture protection and stability of the finished product. Sepifilm™ LP can be used for aqueous, organic or hydroalcoholic phases and different levels of moisture protection can be achieved to suit your formulation needs. Its manufacturing processes are EXCiPACT certified and all components are multicompendial-compliant to Ph. Eur, USP NF.
2. A range of aesthetic coating products
To give an elegant smooth finishing to tablets
Seppic offers a wide range of aesthetic coating options with multiple shades of color depending on the nature of the pigment. Titanium dioxide-free options are available within the different ranges. Sepifilm™ & Sepisperse™ products can be used for pharmaceutical applications, their manufacturing processes are EXCiPACT certified and all components are multicompendial-compliant to Ph. Eur, USP NF.
Aesthetic coating: Range of optimized immediate-release film-coating agents in granule or powder form.
Colored coating: Range of cost-efficient, immediate-release film-coating agents in powder form and also titanium free.
Colored agent: Coloring agent in powder or granule form guaranteeing perfect batch to batch consistency and reproducibility. To be used in combination with a Sepifilm™ product.
Sugar coating: A range of ready-to-use sugar-coating systems in powder form along with a combination of SEPISPERSE™ AS a blend of sugar and coloring agents.
Bright coating is an all-in-one film-coating agent to achieve superior pearlescent effect.
3. Titanium dioxide free film-coatings
Designed with unique ingredients
Seppic proposes a new patented solution, Sepifilm™ White TF with opacifying properties giving a white color to the tablets without titanium dioxide, commonly used for this purpose in tablet coatings. We offer titanium dioxide-free options for the Sepifilm™ Classic, and Sepifilm™LP to be combined with titanium-free Sepisperse™ Dry. Each range can be combined with coloring agent (Sepisperse™) to obtain the color you need accurately and reliably. Our recently launched Sepifilm™ PW TF (titanium free) colored product range helps global pharma customers access the new TiO2 free requirements. The range of Sepifilm PW TF colors is aimed to bring multiple benefits and opportunities to the formulators in addition to the TF advantage. Also the range provides an option to have functional properties like moisture protection when combined with Sepifilm™ LP.
Seppic TiO2 free coatings offer
Mineral free solution, HPMC based to provide strong opacifying properties with a white color to the tablets.
Surfactant Offer
Multicompendial Oral surfactant range:
Our range of emulsifiers & stabilizers are based on performant and well-known chemistries (Polysorbates, Sorbitan esters, Ethoxylated fatty acids or alcohols) used on major drugs worldwide. All of our surfactants manufactured according to pharmaceutical GMP guidelines, with additional quality commitments depending on the intended route of administration:
For Oral use: PHA and PHA PREMIUM ranges are manufactured according to IPEC Good Manufacturing Practices guidelines with EXCiPACT™ certification, and compliant to Ph.Eur. and USP-NF and also a few grades compliant to ChP.
Multicompendial oral surfactant range:
Montane™ PHA Premium range
Montane™ range is composed of different sorbitan ester grades that can be used to formulate water-in-oil emulsions for oral formulations..They can be used alone or combined with Montanox™ to produce highly stable emulsions.
Montanox™ PHA Premium range
The Montanox™ range is composed of different grades of polysorbates that can be used to solubilize active pharmaceutical and/or biological ingredients. Montanox™ products are polyethoxylated sorbitan esters and are characterized by their HLB (Hydrophilic-Lipophilic Balance) value. They are stable in acidic or basic media as well as in the presence of electrolytes, are compatible with other surfactants and can be combined with Montane™ to obtain high stability emulsions.
Powdered Dry Surfactant for solubility improvement
Sepitrap™ is a micro-encapsulated solubilizer in powder form designed to simplify the manufacturing of solid oral form drugs. It is manufactured by adsorption of the solubilizer in liquid form on a porous support.
There are two solubilizers in the Sepitrap™ range:
Sepitrap™ 80 and Sepitrap™ 4000
Designed for solid forms such as tablets and capsules, it can be used in direct compression procedures without impacting the hardness and disintegration of the formed tablets.
There are two kinds of benefits: bioavailability enhancement and manufacturing process optimization:
- It is designed using a patented technology
- It is a free-flowing powder
- It is suited to direct compression processes, there is no intermediary wet granulation required
- It can be used to improve the solubility of active ingredients with low water solubility
Binders & Disintegrants
Video: SEPITRAP™ & HME
Seppic offers Versatile excipient for oral solid dosage form designed for the manufacturing of tablets and capsules.
Sepistab™ ST 200 is a versatile excipient presented in the form of white, odorless granules. It features both the binding and disintegrating properties of the pregelatinized starch and the excellent flow of the native starch, making it a first class, highly versatile excipient.
Sepistab™ ST 200, provides several benefits, related to the manufacturing process for solid forms as well as the improvement of the final formulation.
Process benefits:
- Improves the flow of powders, a key point for direct compression or filling capsules
- Can be used as adsorption medium due to its porosity
- Has an anti-capping action
Formulation benefits:
- Improves the stability of active ingredients sensitive to moisture due to its role as a moisture scavenger and its very low Aw value (water activity).
- Can be used to obtain tablets with a greater hardness without compromising their rapid disintegration in the body, effectively replacing binding and disintegrating agents. The graph below illustrates the performance of SEPISTAB™ ST 200 as a binding and disintegrating agent.
Topical Route
Seppic offers excipients for the dermo pharmaceutical market, with solutions for skin and mucosal applications. The topical administration of drugs allows targeted care of dermatological or loco-regional pathologies. Dermo-pharmaceutical drugs exist largely in semi-solid forms such as gels, creams, and ointments.
Multifunctional polymers : Drivers of innovation for topical formulation
Sepineo™ P600 is multifunctional 3in 1 polymer: thickening, emulsifying, stabilizing and texturing agent. Ready-to-use, it is designed for the formulation such as gels and creams and is very easy to implement. It is easy to use as it does not require neutralization step when developing new gels, creams, simple or multiple emulsions for:
- Formulas for topical application with drug or medical device status
- Formulas with high solvent content, or with rich oily phases
- Products composed of heat sensitive ingredients
- Registered at the CDE
Ready-to-use, it is designed for the formulation of gels and creams and is very easy to implement.
Sepineo™ D.E.R.M is an innovative concentrated polymer ready to use powder form with thickening, stabilizing and texturizing properties. It is pre-neutralized and stable over a pH ranging from 3 to 12. Sepineo™ D.E.R.M can be used to obtain a wide variety of textures: sprays, lotions, thick creams… It can be used to formulate gels, cream-gels, O/W emulsions and Geltrap™ W/O emulsions or even foams, patches, etc. It also can be used to obtain formulas with a highly appreciated sensory profile. The final products are fresh, smooth and non-sticky and compatible with many active ingredients, solvents and fatty phases.
Sepineo™ PHD 100 is a polymer in powder form, dedicated to the formulation of drugs and medical devices for topical, vaginal, rectal & gingival applications.
The most resistant polymeric network
Sepineo™ PHD 100 is an associative polymer combining polyelectrolytic repulsions and hydrophobic groups. This dual mechanism gives to your formulations unparalleled stability, especially under stressful conditions:
- Up to 10% addition of electrolytes without loss of viscosity
- Formulation of ionic APIs (e.g. up to 10% of Lidocaine hydrochloride)
- Combinations of APIs (e.g. Betamethasone / Salicylic acid)
Innovative Emulsifiers
Sepineo™ SE 68 is an emulsifier with vegetal origin designed for the formulation of O/W emulsions for topical applications. Is a non-ionic glucolipid that easily produces very stable oil/water emulsions. It offers many benefits for the formulator, particularly in terms of simplicity of process and compatibility:
- No addition of other emulsifiers or thickening agents in some cases
- No HLB calculation
- Stable over a wide pH range (3 – 11)
- Very good resistance to electrolytes
- Compatible with a large number of excipients
- Compatible with important quantities of solvents – alcohol, propylene glycol – and fatty phases: ideal for anhydrous formulations
- Compatible with many active ingredients
An “active” emulsifier promoter of liquid crystals, forms lamellar bilayers around oil droplets and lamellar phases in the continuous aqueous phase. Is effective over a wide pH range with a good robustness and a high compatibility with APIs and other excipients. Its ability to form liquid crystals improve the stability of emulsions and grant moisturizing properties to the finished formulation.
Simaline™ L80 Liquid polymeric emulsifier for innovative pharmaceutical “Gel-in-Oil” emulsion and for W/O emulsion
Multicompendial Topical surfactant range:
Our range of topical emulsifiers & stabilizers are based on performant and well-known chemistries (Polysorbates, Sorbitan esters, Ethoxylated fatty acids or alcohols) used on major drugs worldwide. All of our surfactants manufactured according to pharmaceutical GMP guidelines, with additional quality commitments depending on the intended route of administration:
For Topical use: PHA and PHA PREMIUM ranges are manufactured according to IPEC Good Manufacturing Practices guidelines with EXCiPACT™ certification, and compliant to Ph.Eur. and USP-NF and also a few grades compliant to ChP.
Montane™ PHA Premium range
Montane™ range is comprised of different sorbitan ester grades that can be used to formulate water-in-oil emulsions for topical formulations.montane™ products can be used in practically all emulsion formulations: creams, ointments, lotions etc.They can be used alone or combined with Montanox™ to produce highly stable emulsions.
Montanox™ PHA Premium range
The Montanox™ range is composed of different grades of polysorbates that can be used to solubilize active pharmaceutical and/or biological ingredients and to formulate oil-in-water emulsions for topical routes. Montanox™ products are polyethoxylated sorbitan esters and are characterised by their HLB (Hydrophilic-Lipophilic Balance) value. They are stable in acidic or basic media as well as in the presence of electrolytes, are compatible with other surfactants and can be combined with Montane™ to obtain high stability emulsions.
Wound healing API
TECA Pharma an Active Pharmaceutical Ingredient for wound healing and venous insufficiency. First Centella asiatica extract to be used for medicinal applications, TECA™ Pharma comes with a more than 50-year track record of use in drug products for wound healing and venous insufficiency.
Parenteral Range
Injectable excipients require the highest quality. Seppic’s range of injectable solubilizing agents and emulsifiers improves the effectiveness of the active ingredients, while meeting the requirements for intravenous, intramuscular or subcutaneous administration. In immunotherapy, the range of vaccine adjuvants contributes to the efficacy of treatment, including oncology.
These ranges are the result of Seppic’s expertise in manufacturing high purity excipients that are EXCiPACT and meet the highest European Good Manufacturing Practice standards. With its excipients, Seppic offers the highest level of safety and reliability to its customers worldwide.
Sepivac SWE™
Sepivac SWE™ is the first GMP oil-in-water adjuvant available in open access suitable for human use. It has already been used in various preclinical and clinical studies and is proven to be a safe and efficient vaccine adjuvant for a wide range of antigens. Moreover, SEPIVAC SWE™ can be an asset in the context of global pandemic response.
The Montane™ PPI range
Montane 20 PPI; Montane 80 PPI; is composed of different sorbitan ester grades that can be used to formulate water-in-oil emulsions for injectable formulations. The PPI grades are designed for injectable administration and products are manufactured according to the Good Manufacturing Practices “GMP part II”. They comply with the Ph. Eur., USP-NFand also a few grades compliant to ChP.
The Montanox™ PPI range
Montanox 20 PPI; Montanox 80 PPI; Montanox 80 API Montanox 80 LPI; ; is composed of different grades of polysorbates that can be used to solubilize active pharmaceutical and/or biological ingredients. The PPI grades are designed for injectable administration and products are manufactured according to the Good Manufacturing Practices “GMP part II” and comply with the Ph. Eur., USP-NF, JP/JPE (and ChP for specific grades).
Discover our range here!
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