Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
Synthesize of the chitosan-TPP coated betanin-quaternary ammonium-functionalized mesoporous silica…
Advanced glycation end products (AGEs) are harmful by-products of thermal-processing of food. Betanin is an antioxidant with the potential to inhibit AGEs formation. In this work, we encapsulated betanin in chitosan-sodium tripolyphosphate coated quaternary ammonium-functionalized mesoporous silica…
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Differential Surface Engineering Generates Core–Shell Porous Silicon Nanoparticles for Controlled…
An approach to differentially modify the internal surface of porous silicon nanoparticles (pSiNPs) with hydrophobic dodecene and the external surface with antifouling poly-N-(2-hydroxypropyl) acrylamide (polyHPAm) as well as a cell-targeting peptide was developed. Specifically, to generate these…
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Effect of Combination of Carbopol-940 Base and HPMC Gel Extract of Aloe Vera Flesh on Physical…
Aloe vera (Aloe chinensis Barker.) has been shown to be efficacious as an antibacterial which has the potential to treat acne caused by the bacteria Propionibacterium acnes. The use of this combination can increase the viscosity, dissolution, diffusion, and bioavailability of the preparation. This…
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Development and Evaluation of Novel Multi-unit Pellet System Formulation of Metoprolol Succinate for…
Abstract
Metaprolol succinate is a highly water-soluble drug with extensive first-pass metabolism. It needs to be administered about 3-4 times a day for optimum therapeutic effect. Conventional extended-release formulations are available but have their own disadvantages. The study was to designed…
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Improving the Powder Properties of an Active Pharmaceutical Ingredient (Ethenzamide) with a Silica…
To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The dry coating performed with different apparatuses (a batch-type high-speed shear mixer (Mechanomill) and a…
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Solubility enhancement study of lumefantrine by formulation of liquisolid compact using mesoporous…
Lumefantrine, exhibits poor bioavailability due to its very low solubility. A liquisolid compact of lumefantrine was prepared with mesoporous silica as a novel coating material. Lactose anhydrous and syloid 244FP were selected as carrier and coating materials respectively. Varying the carrier to…
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AEROSIL® 200 Pharma – well established and ready for tomorrow’s drug production
Evonik is one of the world’s leading CDMOs for advanced drug delivery. Our integrated portfolio of functional excipients, technologies and services for the formulation development, process scale-up and cGMP manufacturing of complex oral and parenteral drug products can reduce your project risk,…
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Fused Deposition Modeling (FDM) 3D Printing of the Thermo-Sensitive Peptidomimetic Drug Enalapril…
Fused deposition modeling (FDM) 3D printing was used to produce 3D printed tablets with the thermo-sensitive model peptidomimetic drug enalapril maleate (EM). Two different formulations were prepared to investigate the degradation of enalapril maleate during the FDM 3D printing process. Soluplus® …
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High-Shear Wet Granulation of SMEDDS Based on Mesoporous Carriers for Improved Carvedilol Solubility
Mesoporous carriers are a convenient choice for the solidification of self-microemulsifying drug delivery systems (SMEDDS) designed to improve the solubility of poorly water-soluble drugs. They are known for high liquid load capacity and the ability to maintain characteristics of dry, free-flowing…
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Sustained and targeted delivery of hydrophilic drug compounds: A review of existing and novel…
The sustained and/or targeted delivery of hydrophilic drugs is an important field within drug delivery, presenting unique challenges when compared to that of hydrophobic drugs. Yet relatively few comprehensive reviews specific to hydrophilic drug delivery have been published recently. In this…
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