Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets
Micronized drug powders are generally unsuitable as tableting feed to produce minitablets due to their cohesivity and poor flow. The silicification of fine paracetamol powder (PCMF) with an optimal concentration range of fumed silica (fSi) reduced the net negative charge of PCMF and improved powder…
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Co–encapsulation of flavonoids with anti–cancer drugs: a challenge ahead
Flavonoids have been considered as promising molecules for cancer treatment due to their pleiotropic properties such as anti–carcinogenic, anti–angiogenic or efflux proteins inhibition. However, due to their lipophilic properties and their chemical instability, vectorization seems compulsory to…
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Mesoporous silica nanocarriers as drug delivery systems for anti-tubercular agents: a review
The treatment and management of tuberculosis using conventional drug delivery systems remain challenging due to the setbacks involved. The lengthy and costly treatment regime and patients' non-compliance have led to drug-resistant tuberculosis, which is more difficult to treat. Also, anti-tubercular…
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Hypothermia-Triggered Mesoporous Silica Particles for Controlled Release of Hydrogen Sulfide to…
Despite the fact that heart transplantation (HTx) is a relatively mature procedure, heart ischemic and reperfusion (I/R) injury during HTx remains a challenge. Even after a successful operation, the heart will be at risk of primary graft failure and mortality during the first year.
In this study,…
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Nano-Silica Carriers Coated by Chloramphenicol: Synthesis, Characterization, and Grinding Trial as a…
Silica nanoparticles were applied as the carrier of chloramphenicol (2,2-dichloro-N-acetamide), and were loaded in a 1% carbopol-based gel (poly(acrylic acid)), which allowed obtainment of an upgraded drug form. The samples of silica materials were obtained by means of modified Stöber synthesis, and…
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A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology,…
Background
Cancer remains one of the leading causes of death worldwide. Docetaxel, first marketed as ‘Taxotere’, has been approved for use as a chemotherapeutic for management of gastric, breast, neck, head, non-small cell lung cancer and prostate cancer.
Main
Taxotere, is a docetaxel formulation…
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pH-responsive silica nanoparticles for the treatment of skin wound infections
Chronic wounds are not only a burden for patients but also challenging for clinic treatment due to biofilm formation. Here, we utilized the phenomenon that chronic wounds possess an elevated local pH of 8.9 and developed pH-sensitive silica nanoparticles (SiNPs) to achieve a targeted drug release on…
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Drug-loaded mesoporous silica on carboxymethyl cellulose hydrogel: Development of innovative 3D…
3D printing has been explored as an emerging technology for the development of versatile and printable materials for drug delivery. However, the alliance of 3D printing and nanomaterials has, to date, been little explored in pharmaceutics. Herein, a mesoporous silica with nanostructured pores,…
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Comparative Study of Powder Carriers Physical and Structural Properties
High specific surface area (SSA), porous structure, and suitable technological characteristics (flow, compressibility) predetermine powder carriers to be used in pharmaceutical technology, especially in the formulation of liquisolid systems (LSS) and solid self-emulsifying delivery systems…
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Targeted biomimetic hollow mesoporous organosilica nanoparticles for delivery of doxorubicin to…
Hollow mesoporous organosilica nanoparticles (HMOSNPs) have provided unique opportunities to improve therapeutic efficacy of the encapsulated drugs due to versatile hybrid frameworks and tunable pore sizes, biodegradable nature and intelligent performance.
Highlights
The efficacy of…
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