Mesoporous Silica: for solubility enhancement of challenging compounds
Browsing Category
Silica
Development of a Hydrophobicity-Controlled Delivery System Containing Levodopa Methyl Ester…
Background: The drug release of antiparkinsonian drugs is an important issue during the formulation process because proper release kinetics can help to reduce the off periods of Parkinson’s disease. A 2-factor, 3-level (32) full-factorial design was conducted to evaluate statistically the influence…
Read More...
Read More...
Direct surface modification of mesoporous silica nanoparticles by DBD plasma as a green approach to…
This paper deals with uniformly surface modification of mesoporous silica nanoparticles by applying dielectric barrier discharge (DBD) plasma as an energy-efficient and green approach. First, the mesoporous silica nanoparticles were synthesized from rice husk (RMSN-D) as an economic and…
Read More...
Read More...
Effects of humidity and glidants on the flowability of pharmaceutical excipients. An experimental…
Granular materials are part of the design, production and final products of different industrial sectors. Powder flowability is a major topic in manufacturing and transport as it is closely related to process feasibility. Nonetheless, the flows of granular materials are not easy to describe or…
Read More...
Read More...
Mesoporous silica: a solution for amorphous stabilization of poor glass formers
Introduction: Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or coprecipitation are…
Read More...
Read More...
Isolation and Quantification of miRNA from the Biomolecular Corona on Mesoporous Silica…
To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles (MSN-NH2) has been performed.
Process parameters including miRNA…
Read More...
Read More...
Biotemplated Hollow Mesoporous Silica Particles as Efficient Carriers for Drug Delivery
We designed three types of hollow-shaped porous silica materials via a three-step biotemplate-directed method: porous hollow silica nanorods, hollow dendritic fibrous nanostructured silica (DFNS), and ultraporous sponge-like DFNS. The first step was making a biotemplate, for which we used cellulose…
Read More...
Read More...
Folic Acid Decoration of Mesoporous Silica Nanoparticles to Increase Cellular Uptake and Cytotoxic…
Breast cancer is the most frequent cancer among women and impacts over two million women each year. Although many different types of anticancer agents are available for breast cancer treatment, doxorubicin is one of the most widely used drug. However, doxorubicin related side effects such as heart…
Read More...
Read More...
Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis
The increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics constitute a public health issue, since tuberculosis still constitutes the primary cause of death in the world due to bacterial infection. Mtb has been shown to produce membrane-derived…
Read More...
Read More...
Effect of carrier type and Tween® 80 concentration on the release of silymarin from amorphous solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug disposition classification system, possessing low solubility, as…
Read More...
Read More...
Impact of Critical Material Attributes (CMAs)-Particle Shape on Miniature Pharmaceutical Unit…
The U.S. Food and Drug Administration (FDA) emphasizes drug product development by Quality by Design (QbD). Critical material attributes (CMAs) are a QbD element that has an impact on pharmaceutical operations and product quality. Pharmaceutical drugs often crystallize as needle-shaped (a CMA)…
Read More...
Read More...