Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
Liqui-Tablet: the Innovative Oral Dosage Form Using the Newly Developed Liqui-Mass Technology
In this study, an attempt was made to produce Liqui-Tablets for the first time. This was carried out through the compaction of naproxen Liqui-Pellets. The incentive to convert the novel Liqui-Pellet into Liqui-Tablet was due to the array of inherent advantages of the popular and preferred tablet…
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Effect of Carrier Type and Tween® 80 Concentration on the Release of Silymarin from Amorphous Solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug disposition classification system, possessing low solubility, as…
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Exploring the role of mesoporous silica nanoparticle in the development of novel drug delivery…
The biocompatible nature of mesoporous silica nanoparticles (MSN) attracted researchers’ attention to deliver therapeutic agents in the treatment of various diseases, where their porous nature, high drug loading efficiency, and suitability to functionalize with a specific ligand of MSN helped to…
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Silica-filled methacrylic composites with extremely high compressive strength
SYLOID® 244 has never been applied as a filler in composites with potential dental application. Therefore, the aim of research was to apply this silica in its unmodified and diazonium salt-modified forms in different mass ratios as fillers in light-cured methacrylic composites.
The effectiveness…
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Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement…
This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT). An NSC was loaded with DUT (dissolved in lipids) and dispersed at a nanoscale level using an entrapment technique.
NSC…
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Mesoporous Silica Nanoparticles for Protein Protection and Delivery
Therapeutic proteins are widely used in clinic for numerous therapies such as cancer therapy, immune therapy, diabetes management and infectious diseases control. The low stability and large size of proteins generally compromise their therapeutic effects. Thus, it is a big challenge to deliver…
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Development of novel darunavir amorphous solid dispersions with mesoporous carriers
The aim of this work was to compare mesoporous carriers based on silica and magnesium aluminosilicate in the amorphous solid dispersion production. Darunavir has been selected as an active pharmaceutical ingredient that is classified as a Class 2 BCS substance and exists in two commercially…
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Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution…
Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as…
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Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica…
The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion (ASD) that was designed as an immediate-release tablet with a high drug load (e.g., 40% w/w) to produce heightened maintenance of drug supersaturation during dissolution testing, which will be henceforth…
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Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process
Purpose
Drug X is high solubility, high permeability BCS/DCS I small molecule drug.
High dose and potential pediatric indication required multiparticulate formulation with not less than 80% drug loading to achieve flexible and low quantity dosing with potential for modified release…
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