Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
A Comparison of Chitosan, Mesoporous Silica and Poly(lactic-co-glycolic) Acid Nanocarriers for…
Efficacious oral delivery of therapeutic proteins remains challenging and nanoparticulate approaches are gaining interest for enhancing their permeability. In this study, we explore the ability for three comparably sized nanocarriers, with diverse physicochemical properties , to successfully…
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Melt Dispersion Adsorbed onto Porous Carriers: An Effective Method to Enhance the Dissolution and…
The objective of the present investigation is to enhance the dissolution and flow properties of raloxifene hydrochloride (RXH), a biopharmaceutical classification system class II drug. Melt dispersion of RXH with polyethylene glycol (PEG) 6000 was prepared by the fusion method. The melt dispersion…
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Cannabidiol aqueous solubility enhancement: Comparison of three amorphous formulations strategies…
Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming and based on trial–error processes. The amorphous form of…
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A study on the influence of the dissolution test factors on in vitro release of ibuprofen from…
Objectives
The aim of this study was to investigate the influence of in vitro release test parameters on the release of ibuprofen from sustained release inert matrix tablets.
Materials and methods
Ibuprofen sustained release inert matrix tablets were manufactured at a laboratory scale using…
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Overcome CBD formulation challenges with solutions from Fuji Chemical
Do you want to develop a tablet, capsule, ODT or a powder for a drink mix or bar using cbd oil and are facing some formulation challenges? FujiChemical offers interesting solutions for this:
Learn more in the following video
FujiSil™ is a highly porous silica material. It allows…
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Porous Nanostructure, Lipid Composition, and Degree of Drug Supersaturation Modulate In Vitro…
The unique nanostructured matrix obtained by silica-lipid hybrids (SLHs) is well known to improve the dissolution, absorption, and bioavailability of poorly water-soluble drugs (PWSDs). The aim of this study was to investigate the impact of: (i) drug load: 3–22.7% w/w, (ii) lipid type: medium-chain…
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Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of…
Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase. In recent years, it has been shown that tolcapone is a potent inhibitor of…
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Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules
Oral ingestion remains as the most convenient route of administration for the application of pharmaceuticals since it is non-invasive and does not require trained personnel to administer the drugs. Despite significant progress in novel oral drug delivery platforms over the past few decades, the oral…
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Hierarchical mesoporous silica templated by the combination of fine emulsion and micelles
Highlights
• Mixed Organized Molecular Systems are formed by the mixture of Kolliphor and P123 templates.
• Hierarchical mesoporous silicas obtained by combining fine emulsion and micelles.
• Porosity features controlled by the weight.
• Ratios between fine emulsion and P123…
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Fine grade engineered microcrystalline cellulose excipients for direct compaction: Assessing…
Recent work showed that contrary to conventional wisdom, fine surface engineered excipients outperform their larger counterparts in blends of highly loaded blends of cohesive drug powders in terms of their packing, flowability and tablet tensile strength. Here, two continuous devices, fluid-energy…
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