Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
Development of novel portable NIR spectroscopy process analytical technology (PAT) tool for…
The aim of this research was to develop a process analytical technology (PAT) tool for monitoring the transformation process of the active ingredient ibuprofen into the fast-dissolving salt ibuprofen sodium during the wet granulation process. Two near-infrared (NIR) spectrophotometers, namely…
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Fine excipient materials in carrier-based dry powder inhalation formulations: The interplay of…
Abstract
The contributions of fine excipient materials to drug dispersibility from carrier-based dry powder inhalation (DPI) formulations are well acknowledged, although they are not fully elucidated. To improve the understanding of these contributions, we studied the influences of the particle…
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Evaluation of Printability of PVA-Based Tablets from Powder and Assessment of Critical Rheological…
Abstract
Fused deposition modeling (FDM) is a rather new technology in the production of personalized dosage forms. The melting and printing of polymer–active pharmaceutical ingredient (API)—mixtures can be used to produce oral dosage forms with different dosage as well as release behavior. This…
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Formulation development, in-vitro and ex-vivo evaluation of dry adsorbed solid lipid nanoparticles:…
Abstract
Aim: The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of olanzapine (OLZ) loaded solid lipid nanoparticles (SLNs) for sustained release.
Materials/methods: OLZ SLNs were prepared by hot melt emulsification and ultrasonication using Precirol ATO 5 (PRE)…
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Topical pickering emulsion versus classical excipients: A study of the residual film on the human…
Abstract
The interest in Pickering emulsions is based on the possibility of replacing classical emulsifiers with solid particles. These emulsions are very attractive in the pharmaceutical field for their stability virtues and as a vehicle to deliver active ingredients. The study aimed to analyze…
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Development of a stability indicating high-performance liquid chromatography method for…
Abstract
This study presents a stability indicating high-performance liquid chromatography HPLC method for the determination of cenobamate (CNB) in presence of its main impurity (CNB H-impurity) and degradation products. The chromatographic separation was carried out on a Thermo BDS Hypersil-C18…
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Colon Drug Delivery Systems Based on Swellable and Microbially Degradable High-Methoxyl Pectin:…
Abstract
Oral colon delivery systems based on a dual targeting strategy, harnessing time- and microbiota-dependent release mechanisms, were designed in the form of a drug-containing core, a swellable/biodegradable polysaccharide inner layer and a gastroresistant outer film. High-methoxyl pectin was…
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Excipient Reactivity and Drug Stability in Formulations
This is about the excipient used for achieving sustained release function undergone chemical reaction with the stabilizing agent used for the drug product leading to product quality failure from the desired dissolution behavior. The generic version of Bupropion HCl SR 150 mg, i.e. sustained (12…
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Investigating the Effectiveness of Different Porous Nanoparticles as Drug Carriers for Retaining the…
Abstract
Pinosylvin monomethyl ether (PsMME) is a natural compound known for its valuable bioactive properties, including antioxidant and anti-inflammatory effects. However, PsMME’s susceptibility to photodegradation upon exposure to ultraviolet (UV) radiation poses a significant limitation to its…
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Design of a Novel Delivery Efficiency Feedback System for Biphasic Dissolving Microarray Patches…
Abstract
Dissolving microarray patches (DMAPs) represent an innovative approach to minimally invasive transdermal drug delivery, demonstrating efficacy in delivering both small and large therapeutic molecules. However, concerns raised in end-user surveys have hindered their commercialization…
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